An Exploratory Study of Autonomic Function Investigations in Hemophiliacs on Homoeopathy Medications Using Impedance Plethysmography

Kundu, Tapas; Barde, Pradip; Jindal, Ghanshyam D; Motiwala, Farooq F.

doi:10.1177/2156587217718750

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…The study done by Kundu et al [25] about the investigations of the autonomic function in hemophiliacs using Impedance Plethysmography, revealed that higher time domain parameter rMSSD for blood flow variability in hemophiliacs as compared with healthy controls that may be reflecting peripheral vascular compensation for reduced vagal activity in the studied patients.…”

Section: Resultsmentioning

confidence: 88%

Untitled

2023

J. Med. Chem. Sci.

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Background: Hemophilia-A is a sex-related hereditary bleeding disorder, like the general populations, mortality from cardiovascular diseases is currently responsible for one-third of deaths in hemophilia patients. Method: A case controlled study was carried out on fifty children; twenty five male with hemophilia-A compared to twenty five healthy male children.12 lead surface ECG, 24 hour holter monitoring and basic echocardiography assessment were done for all participating children. Results: ECG recording revealed that increased heart rate (b/min), QTc/msec, the maximum and QT dispersion in the hemophilia children vs. the control, increased QT dispersion by 24 hour holter in hemophilia children. Reduced time domain parameters for HRV (ms) in hemophilia children were compared to the healthy controls. A significant difference was observed between the diseased and healthy group in the number and frequency of the subject with increased QTc dispersion more than 70 ms detected by ECG, but not by holter. Conclusion:There was an increase in QT dispersion in children with hemophilia that put them at risk for developing dysrhythmia, sympathyvagal imbalance detected by the presence of depressed HRV, and also exposed them to cardiac morbidities and sudden cardiac death.

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Section: Resultsmentioning

confidence: 88%

Untitled

2023

J. Med. Chem. Sci.

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“…Homoeopathic medicines have been proved effective in reducing the bleeding episodes in PWH as well as managing the acute bleeding episodes. [15][16][17][18][19][20][21][22][23][24][25] In such scenario the homoeopathic medicines in reduction of cost of care in PWH needs to be evaluated.…”

Section: Introductionmentioning

confidence: 99%

Assessment of social and economic impact of healthcare with homoeopathy for haemophilia in cognizance with patients’ perspective: a cross-sectional survey

Rita

Kundu

Afroz

et al. 2023

Int J Community Med Public Health

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Background: Haemophilia imposes clinical as well as an economical burden on family and society. To assess the social and economic impact of healthcare in haemophilia from patients’ perspective a questionnaire was formed. Out of 900 patients treated at homoeopathy in haemophilia centers, 478 patients participated in the survey in the time period of January 2017 to June 2017. This questionnaire consisted of five categories. Part A included preliminary information, part B included the disease information, part C included direct cost incurred in terms of factor therapy, and part D included indirect cost incurred whereas part E included additional information regarding therapy satisfaction. Methods: It was a cross-sectional survey-based study. Simple random sampling was used for sample collection at the multicentres of homoeopathy in haemophilia. Study duration was 5 months. Selection criteria was patients diagnosed with haemophilia and patients willing to participate in the survey. Ethical approval was received from Institutional Ethics Committee of Motiwala (National) Homoeopathic Medical College, Nasik, Maharashtra, India. Average was calculated to summarize the data, mentioned in discussion. Results: 56% haemophilia patients benefitted with homoeopathy treatment with SOS use of factor, 28% patients experienced homoeopathy is beneficial therapy and 16% patients experienced conservative management. 95.6% patients experienced satisfaction with treatment. 95.2% patient said homoeopathy is most economic therapy, 1.3% patient said it is a conservative management and 3.6% did not acknowledge anything. Conclusions: According to patients’ perspective, homoeopathic therapy was found to reduce the cost of care and burden of high-cost management.

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Heart Rate Variability (HRV) as a Marker of Improved Autonomic Function in PMS: A Homeopathy Intervention-Based Single Blind Randomized Control Study

Barde,

Dahad

et al. 2024

NMO Journal

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Introduction: Pre-menstrual syndrome (PMS) is a prevalent condition contributing to a spectrum of physical and psychological symptoms during the menstrual cycle. Heart rate variability (HRV) stands as a potential tool to delve into the autonomic nervous system’s intricacies. This study aims to bridge this knowledge gap by investigating the relationship between HRV and PMS while concurrently evaluating the efficacy of individualised homoeopathic interventions in managing PMS. Materials and Methods: A prospective case–control study was conducted from August 2020 to April 2021, involving 37 young females aged 16–45 years with diagnosed PMS. Participants were selected through purposive sampling, meeting the Diagnostic and Statistical Manual of Mental Disorders-IV criteria and were randomised into the case (homoeopathy intervention) and control (placebo) groups. Individualised homoeopathic medicines were administered to the case group, while the control group received a placebo. Both groups were followed for 6 months. Autonomic function was assessed using HRV, employing NICOMON, and clinical improvement was evaluated through the Menstrual Distress Questionnaire (MDQ). Statistical analysis included paired t-tests and Pearson’s correlation coefficient. Results: Out of the initially screened 37 subjects, 31 completed the study. The homoeopathy group (n = 15) demonstrated a highly significant improvement in MDQ scores compared to the placebo (n = 16) group (P < 0.00001). HRV analysis revealed significant increases in total power, low-frequency, high-frequency, root mean square of successive normal-to-normal interval differences, NN50 and pNN50%, indicating enhanced autonomic modulation and parasympathetic dominance in the homoeopathy group (P < 0.001, P = 0.006, P = 0.006, P = 0.039, P < 0.001 and P = 0.013, respectively). The miasmatic analysis highlighted an 80% prevalence of sycotic miasm in the PMS cases. Conclusion: Individualised homoeopathic interventions resulted in substantial improvements in autonomic function, as evidenced by HRV metrics, and clinical symptoms in PMS patients. The study sheds light on the potential therapeutic impact of homoeopathy in achieving autonomic balance and relieving PMS symptoms. While acknowledging the study’s limitations, including sample size, these findings suggest avenues for further research in this domain.

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An Exploratory Study of Autonomic Function Investigations in Hemophiliacs on Homoeopathy Medications Using Impedance Plethysmography

Cited by 3 publications

References 13 publications

Untitled

Untitled

Assessment of social and economic impact of healthcare with homoeopathy for haemophilia in cognizance with patients’ perspective: a cross-sectional survey

Heart Rate Variability (HRV) as a Marker of Improved Autonomic Function in PMS: A Homeopathy Intervention-Based Single Blind Randomized Control Study

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