“…Consequently, the experience of social isolation is aversive and impacts both our brains and our behaviors. While long-term isolation can lead to the emergence of anti-social behaviors in both humans and rodents (An et al, 2017; Arrigo and Bullock, 2008; Check et al, 1985; Hossain et al, 2020; Killgore et al, 2021; Ma et al, 2011, 2022; Machimbarrena et al, 2019; Matsumoto et al, 2005; Mears and Bales, 2009; Reid et al, 2022; Toth et al, 2011; Valzelli, 1973; Weiss et al, 2004; Wiberg and Grice, 1963; Zelikowsky et al, 2018), short-term isolation typically increases levels of social motivation and promotes social-seeking behaviors (Baumeister and Leary, 1995; Cacioppo et al, 2006; Cacioppo and Cacioppo, 2018; House et al, 1988; Lee et al, 2021; Niesink and van Ree, 1982; Panksepp and Beatty, 1980; Zhao et al, 2021). Alterations in social motivation are characteristic of many neurodevelopmental disorders, including autism spectrum disorder (Chevallier et al, 2012; Clements et al, 2018).…”