As a promising area in healthcare research, electronic health (e-health) has received more research attention recently. The purpose of this paper is to develop and validate a proposed conceptual framework for digital health literacy. This conceptual framework is planned as a guide for future studies to use and validated as a foundation for quantitative studies to investigate the e-Health Literacy as perceived by citizens in Asia amid the outback of the world’s high-risk pandemic crisis such as Coronavirus (Covid19). This conceptual analysis applied Technology Acceptance Model as a basis to develop the antecedents of a healthy lifestyle among the citizens of Asian countries. This conceptual paper proposed that Information quality, system quality, and service quality will affect the citizens’ perceived ease of use and their perceived usefulness, which can affect their intention to use e-health and consequently results in a healthy lifestyle among the citizens. This conceptual paper submitted research hypotheses that will be a basis for future researches in Asia and if the framework is validated, recommendations will be offered to various stakeholders on how to improve a healthy lifestyle in Asia. Specifically, the proposed conceptual framework if validated will help policymakers to offer positive policies and procedures for the improvement of thriving healthcare industries in Asia.