An Exploratory Study to Determine the Association Between Assessed Facial Skin Aging and Plasma Isoprostane Levels in Middle-Aged Japanese Women

Chang, Anne Lynn S.; Lingala, Bharathi; Chang, Tiffany; Kern, Dale; Wood, Steve M; Toyoda, Hidekazu; Knaggs, H.

doi:10.1111/j.1524-4725.2011.02235.x

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Lipid species previously assigned as isoPGF2a modifications of PAPC and SAPC were induced weakly by UVA, strongly by UVPAPC, and increased further at 24 h. Isoprostanoid modifications of PAPC were described as most efficient inducers of UPR genes [27] via activation of the transcription factor ATF4 [55] . Individuals with increased skin photoaging have reportedly higher levels of plasma isoprostanes [15] and as a result of UVB exposure [66] .…”

Section: Discussionmentioning

confidence: 99%

A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids

et al. 2019

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Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators would be generated in primary human keratinocytes (KC) upon exposure to ultraviolet A light (UVA) and investigated the contribution of OxPL to UVA responses. Mass spectrometric analysis immediately or 24 h post UV stress revealed significant changes in abundance of 173 and 84 lipid species, respectively. We identified known and novel lipid species including known bioactive and also potentially reactive carbonyl containing species. We found indication for selective metabolism and degradation of selected reactive lipids. Exposure to both UVA and to in vitro UVA - oxidized phospholipids activated, on transcriptome and proteome level, NRF2/antioxidant response signaling, lipid metabolizing enzyme expression and unfolded protein response (UPR) signaling. We identified NUPR1 as an upstream regulator of UVA/OxPL transcriptional stress responses and found this protein to be expressed in the epidermis. Silencing of NUPR1 resulted in augmented expression of antioxidant and lipid detoxification genes and disturbed the cell cycle, making it a potential key factor in skin reactive oxygen species (ROS) responses intimately involved in aging and pathology.

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Section: Discussionmentioning

confidence: 99%

A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids

et al. 2019

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Proposed global drooping and wrinkles classification and scoring system for aging face with validation and experience on 54 Indian subjects

Garg¹,

Khan²,

Makadia³

2018

Indian J Dermatol Venereol Leprol

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This is a new clinical classification and scoring system for facial age which is much easier to apply in daily clinical practice for easy calculation of baseline scores and customizing their antiaging treatment options. Moreover, it will also make it easier to compare the efficacy of treatment in their future follow-ups. The limitation of this study is that it has been proposed for all skin types but validation has been done only for Indian participants.

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An Exploratory Study to Determine the Association Between Assessed Facial Skin Aging and Plasma Isoprostane Levels in Middle-Aged Japanese Women

Abstract: Plasma isoprostanes as markers of accelerated aging of the skin merit further study.

Cited by 2 publications

References 25 publications

A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids

A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids

Proposed global drooping and wrinkles classification and scoring system for aging face with validation and experience on 54 Indian subjects

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