Higher order non‐Fickian diffusion theories involve fourth‐order linear partial differential equations and their solutions. A quintic polynomial spline technique is used for the numerical solutions of fourth‐order partial differential equations with Caputo time fractional derivative on a finite domain. These equations occur in many applications in real life problems such as modeling of plates and thin beams, strain gradient elasticity, and phase separation in binary mixtures, which are basic elements in engineering structures and are of great practical significance to civil, mechanical, and aerospace engineering. The quintic polynomial spline technique is used for space discretization and the time‐stepping is done using a backward Euler method based on the L1 approximation to the Caputo derivative. The stability and convergence analysis are also discussed. The numerical results are given, which demonstrate the effectiveness and accuracy of the numerical method. The numerical results obtained in this article are also compared favorably well with the results of (S. S. Siddiqi and S. Arshed, Int. J. Comput. Math. 92 (2015), 1496–1518). © 2016 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 33: 445–466, 2017