An Extended 10-Core Transrectal Ultrasonography Guided Prostate Biopsy Protocol Improves the Detection of Prostate Cancer

Eskiçorapçı, Saadettin; Baydar, Dilek Ertoy; Akbal, Cem; Sofikerim, Mustafa; Günay, Murat; Ekici, Sinan; Özen, Haluk

doi:10.1016/j.eururo.2003.11.024

Cited by 125 publications

(88 citation statements)

References 19 publications

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“…Therefore, the false negative rate of TRUS-guided biopsies is a major concern. It is well known that cancer detection by TRUS-guided biopsy can be improved by increasing the number of removed cores and by contrast-enhanced-targeted biopsies (6)(7)(8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the MRI-guided biopsy technique provides an alternative to TRUS-guided biopsy in patients with abnormal PSA values (19,20). The prostate cancer detection rate of TRUS-guided biopsy decreases with every rebiopsy and increases with the number of cores collected (4,6,8). This phenomenon is most likely due to the systematic biopsy approach of TRUS biopsies compared to a targeted biopsy technique, such as direct MRI-guided biopsy, which should not be affected by prior biopsies.…”

Section: Discussionmentioning

confidence: 99%

“…The old, standard 6-core TRUS-guided biopsy approach obtains mainly midlobar parasagittal cores and is not sufficient for detecting prostate cancer (24,25). For TRUS-guided biopsies, higher detection rates can be achieved by increasing the number of core samples (6,7,26). Studies performed with a sampling of up to 21 cores by TRUS-guided biopsy yielded higher detection rates than biopsy regimens involving the removal of fewer cores (8).…”

Section: Discussionmentioning

confidence: 99%

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MR-guided biopsy of the prostate: correlation of cancer detection rate with number of previous negative TRUS biopsies

Durmus¹,

Reichelt²,

Huppertz³

et al. 2013

Diagn Interv Radiol

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ORIGINAL ARTICLE PURPOSE We aimed to investigate prostate cancer detection rate of magnetic resonance imaging (MRI)-guided biopsy and to elucidate possible relations to the number of prior negative transrectal ultrasonography (TRUS)-guided biopsies. MATERIALS AND METHODSEighty-seven consecutive patients (mean age, 65.0 years; mean prostate-specific antigen, 13.3 ng/mL) with at least one prior negative TRUS-guided biopsy and persistent suspicion of prostate cancer were included in this study. All patients underwent MRI-guided biopsy after a diagnostic multiparametric MRI examination at 1.5 Tesla. Specimens were immediately fixated and subsequently evaluated by an experienced uropathologist. Prostate cancer detection rates were calculated. Prostate cancer-positive and -negative cores were compared. Correlation between number of prior biopsies and presence of prostate cancer was evaluated. RESULTSCancer detection rates for patients with one (n=24), two (n=25), three (n=18), and four or more (n=20) negative TRUS-guided biopsies were 29.2%, 40.0%, 66.7%, and 35.0%, respectively (P = 0.087). The median number of removed cores per patient was 3 (range, 1-8) without a significant difference between patients with and without cancer (P = 0.48). Thirty of 36 cancer patients were at intermediate or high risk according to the D´Amico clinical risk score. Eleven of 15 high risk cancers were localized in the transition zone (P = 0.002). CONCLUSIONSThis study demonstrates high cancer detection rates of MRI-guided biopsy independent of the number of previous TRUS-guided biopsies and the number of taken prostate cores. MRI-guided biopsy therefore represents a less invasive and effective diagnostic tool for patients with prostate cancer suspicion and previous negative TRUS-guided biopsies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

MR-guided biopsy of the prostate: correlation of cancer detection rate with number of previous negative TRUS biopsies

Durmus¹,

Reichelt²,

Huppertz³

et al. 2013

Diagn Interv Radiol

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“…Urological stud- ies in particular have shown that the detection rate increases as expected with the number of samples so that approximately 6 samples are currently taken from each lateral lobe in accordance with the recommendations of the professional associations [38,39]. However, the entire context of the diagnostic weaknesses of TRUS biopsy only becomes clear with MR imaging and visualization of prostate cancer [40].…”

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confidence: 88%

Multiparametric Magnetic Resonance Imaging in the Detection of Prostate Cancer

Durmus

Baur

Hamm

2014

Fortschr Röntgenstr

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!Prostate cancer is the most common malignancy in men, but only about 10 % of patients die from that cancer. Recent studies suggest that not all patients benefit from a radical therapeutic approach. When prostate cancer is suspected, magnetic resonance imaging (MRI) can make an important contribution to cancer localization within the prostate. Many studies show that T2-weighted morphologic imaging should be supplemented by multiparametric MRI techniques including diffusion-weighted imaging, contrast-enhanced sequences, and MR spectroscopy. This approach detects aggressive prostate cancer with high sensitivity and specificity. The findings of multiparametric MRI additionally contribute information to the assessment of cancer aggressiveness. The use of these multiparametric MRI techniques will gain an increasing role in the clinical management of prostate cancer patients. They can help in establishing a definitive diagnosis with a minimum of invasiveness and may also contribute to optimal individualized treatment. This review article presents the different techniques of multiparametric MRI and discusses their contribution to the detection of prostate cancer. Moreover, this review outlines an objective approach to image interpretation and structured reporting of MRI findings using the PI-RADS criteria. The review concludes with an outline of approaches to prostate biopsy on the basis of MRI (transrectal ultrasound, direct MRI guidance of tissue sampling, and MRI-ultrasound fusion biopsy) and emerging future uses of MRI in the planning of focal treatment options and in the active surveillance of patients diagnosed with prostate cancer.Citation Format:

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“…[1][2][3] Recent modifications of biopsy technique, including lateral sampling of the peripheral zone of the gland and an increase in the number of biopsy cores, have increased the detection rates of prostate carcinoma. 4,5 The primary reason for oversampling of the peripheral zone of the gland comes from the premise that the majority of prostate tumors originate from this region of the prostate. 6,7 In this issue of Cancer, Demura et al challenge some commonly accepted concepts regarding the zonal distribution of prostate carcinoma.…”

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confidence: 99%

Carcinoma core distribution in patients with palpable and nonpalpable prostate tumors

Hernández

Thompson

2005

Cancer

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Introduction of prostate‐specific antigen (PSA)–based screening for prostate carcinoma has led to a significant increase in the detection of prostate carcinoma. Prostate core needle biopsy remains the gold standard as a diagnostic tool with which to ascertain disease status. In this issue of Cancer, Demura et al. challenge some commonly accepted concepts regarding the zonal distribution of prostate carcinoma and explore the distribution of carcinoma cores within the prostate as well as the potential impact of a systematic, ultrasound‐guided transperineal template biopsy in improving carcinoma detection rates.

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An Extended 10-Core Transrectal Ultrasonography Guided Prostate Biopsy Protocol Improves the Detection of Prostate Cancer

Cited by 125 publications

References 19 publications

MR-guided biopsy of the prostate: correlation of cancer detection rate with number of previous negative TRUS biopsies

MR-guided biopsy of the prostate: correlation of cancer detection rate with number of previous negative TRUS biopsies

Multiparametric Magnetic Resonance Imaging in the Detection of Prostate Cancer

Carcinoma core distribution in patients with palpable and nonpalpable prostate tumors

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