2006
DOI: 10.1016/j.snb.2006.01.018
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An extended gate FET-based biosensor integrated with a Si microfluidic channel for detection of protein complexes

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Cited by 100 publications
(63 citation statements)
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“…Removing atoms from the membrane produced an hourglass pore, whose shape closely resembles that of the pores sputtered by a highly-focused electron beam. 25,26 In the middle of the membrane, the pore's shape is a cylinder of a 1-nm diameter and a 1-nm height. The pore gradually opens to both sides of the membrane at a 30° angle.…”
mentioning
confidence: 99%
“…Removing atoms from the membrane produced an hourglass pore, whose shape closely resembles that of the pores sputtered by a highly-focused electron beam. 25,26 In the middle of the membrane, the pore's shape is a cylinder of a 1-nm diameter and a 1-nm height. The pore gradually opens to both sides of the membrane at a 30° angle.…”
mentioning
confidence: 99%
“…Changes of the channel conductance of FETs are caused by shifting the potential difference, which results in shifts of the electrical properties of FETs. [20][21][22] Therefore, the shifts of the transfer curve and the threshold voltage of the fabricated OFET device with increasing human IgA concentration are probably due to the interfacial potential shift at the extended-gate/solution interface, suggesting that the positively charged IgA was captured on the extended-gate electrode. In addition, the gate currents did not significantly change during the titration, suggesting that electrochemical reactions (such as electrolysis) did not occur at the gate electrode 21,23 (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, the stability of the gate current suggests that no electrochemical reaction (i.e., the electrolysis of water) was caused by applying the gate voltage. 25,26 Taken together, the enzymatic redox chain reaction on the extendedgate electrode brought about the observed changes in the OFET transfer characteristics. The relationship between the histamine concentration and changes in the threshold voltage (VTH) are summarized in Fig.…”
Section: Changes In Ofet Transfer Characteristics With the Addition Omentioning
confidence: 87%