High-energy messengers from the Universe comprise charged cosmic rays, gamma rays and neutrinos. Here we summarize the detection principles and detection schemes for these particles, with a focus on ground-based instruments which employ natural media such as air, ice, or water as their detection medium.High energy astrophysics is concerned with the study of non-thermal particle populations in our Galaxy and beyond, with their sources, propagation, and impact on their cosmic environment. This field relies on detectors for highenergy messengers from the Universe -the subject of this article -but also on astrophysical instruments in many other domains of the electromagnetic spectrum, most notably in the radio and X-ray, tracing the synchrotron radiation of high energy electrons. For the current discussion, we will -somewhat arbitrarily -concentrate on the domain from GeV energies up, where the detectors address common science themes and share many detection features; MeV instruments differ in terms of their science focus but also in their detection principles.2 Given that typical Galactic radiation fields provide U ≈ 1 eV/cm 3 , the lifetime of cosmic-ray electrons is limited to τyr ≈ 3 · 10 5 /E e,TeV and hence their range to √ Dτ ≈ 1kpc/E 0.25 e,TeV .