An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high‐fat “Western‐type” diet in mice

Jurado-Ruíz, Enrique; Varela, Lourdes M.; Luque, Amparo; Berná, Genoveva; Cahuana, Gladys M.; Martı́n, Franz; Gallego‐Durán, Rocío; Soria, Bernat; Roos, Baukje de; Romero‐Gómez, Manuel

doi:10.1002/mnfr.201600549

Cited by 43 publications

(49 citation statements)

References 38 publications

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“…Interestingly, at 24 h postinjection, most of the E‐MPNs were eliminated from the spleen, liver, and lungs, with only about 1%, 10%, and 0.5% remaining, respectively, indicating that the particles are biodegradable in these organs over time. This property is likely related to the stability of the MPN coating with pH and the metabolism of fatty acids in the liver (i.e., OA) . All animals survived the study—mice were active and showed no signs of lethargy or ill health after being dosed with known quantities of E‐MPNs.…”

Section: Resultsmentioning

confidence: 99%

Self‐Assembled Metal–Phenolic Networks on Emulsions as Low‐Fouling and pH‐Responsive Particles

Besford

Wang

et al. 2018

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Interfacial self-assembly is a powerful organizational force for fabricating functional nanomaterials, including nanocarriers, for imaging and drug delivery. Herein, the interfacial self-assembly of pH-responsive metal-phenolic networks (MPNs) on the liquid-liquid interface of oil-in-water emulsions is reported. Oleic acid emulsions of 100-250 nm in diameter are generated by ultrasonication, to which poly(ethylene glycol) (PEG)-based polyphenolic ligands are assembled with simultaneous crosslinking by metal ions, thus forming an interfacial MPN. PEG provides a protective barrier on the emulsion phase and renders the emulsion low fouling. The MPN-coated emulsions have a similar size and dispersity, but an enhanced stability when compared with the uncoated emulsions, and exhibit a low cell association in vitro, a blood circulation half-life of ≈50 min in vivo, and are nontoxic to healthy mice. Furthermore, a model anticancer drug, doxorubicin, can be encapsulated within the emulsion phase at a high loading capacity (≈5 fg of doxorubicin per emulsion particle). The MPN coating imparts pH-responsiveness to the drug-loaded emulsions, leading to drug release at cell internalization pH and a potent cell cytotoxicity. The results highlight a straightforward strategy for the interfacial nanofabrication of pH-responsive emulsion-MPN systems with potential use in biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Self‐Assembled Metal–Phenolic Networks on Emulsions as Low‐Fouling and pH‐Responsive Particles

Besford

Wang

et al. 2018

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“…Fatty acid analysis and determination of total phenols was assessed as previously described . The olive oil used in the HFD‐EVOO group presented a 79.58% of oleic acid respect to total fatty acid content and 79 mg kg –1 of total phenolic compounds expressed as tyrosol equivalents, and the olive oil used in the HFD‐OL group, a 77.66% of oleic acid and 444 mg kg –1 of total phenolic compounds.…”

Section: Methodsmentioning

confidence: 99%

Extra‐Virgin Olive Oil with Natural Phenolic Content Exerts an Anti‐Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr−/−.Leiden Mice

Luque-Sierra

Álvarez-Amor

Kleemann

et al. 2018

Molecular Nutrition Food Res

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“…Animal studies have shown that oils high in MUFAs or PUFAs have attenuated the effects of dietaryinduced NAFLD. Mice that were fed an HF diet (49% energy from fat) for 12 wk and fed phenol-rich extra virgin olive oil (41.7% energy from olive oil) had an improved lipid profile, decreased visceral adipocyte inflammatory cytokine expression, and improved NASs compared with mice fed an HF diet without extra virgin olive oil (83). The mean NAS of mice fed the HF diet was >4, whereas mice fed the extra virgin olive oil and phenol-rich extra virgin olive oil had NASs of 3 and 2, respectively (83).…”

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confidence: 99%

“…Mice that were fed an HF diet (49% energy from fat) for 12 wk and fed phenol-rich extra virgin olive oil (41.7% energy from olive oil) had an improved lipid profile, decreased visceral adipocyte inflammatory cytokine expression, and improved NASs compared with mice fed an HF diet without extra virgin olive oil (83). The mean NAS of mice fed the HF diet was >4, whereas mice fed the extra virgin olive oil and phenol-rich extra virgin olive oil had NASs of 3 and 2, respectively (83). In addition, menhaden oil, which is rich in PUFAs such as EPA (20:5n-3) and DHA (22:6n-3), has been shown to improve the hepatic damage induced by a high-fat, high-cholesterol (HFHCH) diet in both wildtype mice and genetic animal models of hyperlidemia (84).…”

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confidence: 99%

Nutritional Approaches to Achieve Weight Loss in Nonalcoholic Fatty Liver Disease

Hsu

Ness

Kowdley

2017

Advances in Nutrition

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Nonalcoholic fatty liver disease (NAFLD) can range in spectrum from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which is characterized by lipotoxicity, hepatocellular ballooning, and inflammation and can progress to cirrhosis. Weight loss is the cornerstone treatment for NAFLD and NASH. Various randomized controlled trials have shown that weight loss of $5-10% leads to significant improvements in hepatic steatosis. Diets high in sodium and fructose have been implicated in the pathogenesis of NAFLD. Although some clinical studies suggest that an isocaloric high-fructose diet does not worsen NAFLD, these clinical studies are often short in duration. More recently, the Dietary Approaches to Stop Hypertension diet, a sodium-restricted diet, has been associated with less prevalence of NAFLD and has been shown to improve NAFLD. In addition, the Mediterranean diet has been promising in improving hepatic steatosis, and a larger randomized controlled trial is currently enrolling subjects. For those who are unable to pursue weight loss through dietary approaches, bariatric surgery has been shown to improve hepatic steatosis and steatohepatitis. This method has been variable in improving hepatic fibrosis. In conclusion, weight loss is crucial to the improvement of NAFLD and NASH, and patients should attempt various diets in an attempt to achieve weight loss. Adv Nutr 2017;8:253-65.

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An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high‐fat “Western‐type” diet in mice

Abstract: Dietary EVOO could repair HFD-induced hepatic damage, possibly via an anti-inflammatory effect in adipose tissue and modifications in the liver lipid composition and signaling pathways.

Cited by 43 publications

References 38 publications

Self‐Assembled Metal–Phenolic Networks on Emulsions as Low‐Fouling and pH‐Responsive Particles

Self‐Assembled Metal–Phenolic Networks on Emulsions as Low‐Fouling and pH‐Responsive Particles

Extra‐Virgin Olive Oil with Natural Phenolic Content Exerts an Anti‐Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr−/−.Leiden Mice

Nutritional Approaches to Achieve Weight Loss in Nonalcoholic Fatty Liver Disease

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