An Extraordinary Association of Glomus Tumor and Pacinian Hyperplasia in the Hand of a Female Patient

Komforti, Miglena K.; Cummings, Thomas J.

doi:10.1097/dad.0000000000000374

Cited by 10 publications

(17 citation statements)

References 3 publications

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“…The histology of Pacinian corpuscles has often been reported routinely in relation to various pathologic conditions in the skin of adult hands (e.g., Barbolini et al, 1971;Greider and Flatt, 1982;Komforti and Cummings, 2015;Garcia et al, 2015). A comprehensive evaluation of adult human corpuscles by routine histologic methods showed a highly wavy or coiled appearance (Cauna and Mannan, 1958).…”

Section: Introductionmentioning

confidence: 99%

Pacinian Corpuscles in the Human Fetal Finger and Thumb: A Study Using 3D Reconstruction and Immunohistochemistry

Kim

Park

Yang

et al. 2017

The Anatomical Record

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The detailed distribution of Pacinian corpuscles was evaluated by viewing the transverse sections of all fingers and thumbs, including the interdigital areas, from eight hands of five fetuses of gestational age 28-33 weeks (crown-rump length 230-290 mm). Among the 40 fingers and thumbs, serial sections were prepared for 3D reconstructions of nerve elements in the distal and middle phalangeal segments of three fifth fingers; in these three fingers, the distal segment contained 45-75 Pacinian corpuscles. These Pacinian corpuscles were 0.2-1.0 mm in length and 0.05-0.3 mm in thickness, oriented along the proximodistal axis and arranged along the palmar digital nerve branches. Other than beneath the digital skin, small corpuscles (<0.1 mm in thickness) were observed within the tendon sheath of the flexors in the middle or distal segment of five fetuses and in the nail beds of four fetuses. Clusters of 5-20 corpuscles formed bouquet- or tree-like arrangements along neurovascular bundles in the fingers, thumbs and interdigital areas. Because the space beneath the skin was thick and loose in the interdigital area, trees in the interdigital area were up to 2 mm long. Regardless of site, the central core of each corpuscle was positive for S100 protein, while the core and parts of the capillaries in the corpuscle were weakly positive for nestin. Because corpuscles in the tendon sheath and nail bed, as well as bouquet- and tree-like arrangements of corpuscles, have not been reported in adults, these morphologies are likely specific to fetuses. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 301:154-165, 2018. © 2017 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Pacinian Corpuscles in the Human Fetal Finger and Thumb: A Study Using 3D Reconstruction and Immunohistochemistry

Kim

Park

Yang

et al. 2017

The Anatomical Record

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“…The coexistence of PCNH with other lesions, such as glomus tumour, Dupuytren’s contracture, foreign body reaction, neurofibromatosis type 1, type 2A burns, and congenital macrodactyly has been described (31%) (Akyürek et al., 2000; Greider and Flatt, 1982; Komforti and Cummings, 2015; Mahipathy et al., 2015; Rinaldi et al., 2000; von Campe et al., 2012; Yan et al., 2006; Yenidunya et al., 2009).…”

Section: Resultsmentioning

confidence: 99%

Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review

Fassola

Wenzke

Ertel

et al. 2019

J Hand Surg Eur Vol

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Tumours involving Pacinian corpuscles are rare. The literature identifies two main pathological disorders: the Pacinian corpuscle neuroma or hyperplasia and the Pacinian corpuscle neurofibroma. Published data are confusing and at times conflicting. This systematic review summarizes the available data in order to support clinicians in the differential diagnosis with other tumours responsible for unclear symptoms in the hands and fingers. We identified 67 pertinent articles. Although some similarities have been described, the two tumours have relevant differences, specifically when comparing age of the patient, location, symptoms, characteristic of a mass, and aetiology. All these factors should be taken into account in order to improve diagnostic accuracy. Despite the low incidence of unsuccessful surgeries, extraordinary measures are occasionally necessary to achieve complete resolution of symptoms.

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“…In very rare cases, glomus tumors and hyperplasia of VP corpuscles may occur in the finger at the same site of pain triggering [ 19 ], [ 20 ]. None of the reports mentioned NF1 as the underlying disease of the patients.…”

Section: Discussionmentioning

confidence: 99%

Painful Vater-Pacini neuroma of the digit in neurofibromatosis type 1

Friedrich

Hagel

2019

GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW; 8:Doc03

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An Extraordinary Association of Glomus Tumor and Pacinian Hyperplasia in the Hand of a Female Patient

Abstract: The association of glomus tumor with Pacinian hyperplasia has rarely been reported in the literature. We present another rare case to bring awareness to this differential diagnostic consideration.

Cited by 10 publications

References 3 publications

Pacinian Corpuscles in the Human Fetal Finger and Thumb: A Study Using 3D Reconstruction and Immunohistochemistry

Pacinian Corpuscles in the Human Fetal Finger and Thumb: A Study Using 3D Reconstruction and Immunohistochemistry

Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review

Painful Vater-Pacini neuroma of the digit in neurofibromatosis type 1

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