An extreme case of cherubism

Silva, E.C.; Souza, Paulo Eduardo Alencar; Barreto, D.C.; Dias, R.; Gomez, Ricardo Santiago

doi:10.1054/bjom.2001.0654

Cited by 35 publications

(22 citation statements)

References 12 publications

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“…The most accepted theory regarding the pathogenesis of cherubism is its association with an autosomal dominant gene, i.e., family inheritance [1-9,11-17,23,35]. However, there are reports of the cases in which no criteria of heredity could be established [1-3,9,11,12,15,16,24], or in which an autosomal recessive pattern of inheritance was suggested [5]. In addition to genetic factors, Caballero and Vinals [14] indicated other possible causes of cherubism such as mesenchymal alterations during jaw development, an odontogenic origin or even hormonal and traumatic factors.…”

Section: Resultsmentioning

confidence: 99%

Cherubism: Clinicoradiographic Features and Treatment

Lima¹,

Almeida²,

Cabral

2010

JOMR

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ObjectivesCherubism is a congenital childhood disease of autosomal dominant inheritance. This disease is characterized by painless bilateral enlargement of the jaws, in which bone is replaced with fibrous tissue. The condition has sui generis clinical, radiographic and histological features, of which the clinician should be aware for a better differential diagnosis in the presence of a fibro-osseous lesion affecting the bones of the maxillomandibular complex. The purpose of present paper was to review the literature and to report the most important aspects of cherubism in order to facilitate the study of this diseaseMaterial and MethodsLiterature was reviewed about cherubism, emphasizing the relevant clinicoradiographic features and treatment. Literature was selected through a search of PubMed and Scielo electronic databases. The keywords used for search were adolescent, cherubism, cherubism/physiopathology, cherubism/treatment, cherubism/radiography. A manual search of the reference lists of the identified articles and the authors' article files and recent reviews was conducted to identify additional publications. Those studies that described new features about cherubism were included in this review.ResultsIn total 44 literature sources were obtained and reviewed. Studies that described new features about cherubism physiopathology, diagnostics and treatment were reviewed.ConclusionsDespite the exceptions, cherubism is a clinically well-characterized disease. In cases of a suspicion of cherubism, radiographic examination is essential since the clinical presentation, the location and distribution of the lesions may define the diagnosis. Histopathological examination is complementary. Nowadays, genetic tests should be used for final diagnosis of cherubism.

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Section: Resultsmentioning

confidence: 99%

Cherubism: Clinicoradiographic Features and Treatment

Lima¹,

Almeida²,

Cabral

2010

JOMR

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“…Radiographically, it is justified by the perforation and disruption of wide areas of the bony cortex and marked root resorption, which has long been considered to be a more aggressive process 1,5,15,19,28 as was found in some cases presented in our current report. SILVA et al 24 reported an extreme case of cherubism that behaved in a locally aggressive manner. An 8-yearold boy presented with severe facial swelling.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic study of 24 cases of cherubism

Meng

2005

International Journal of Oral and Maxillofacial Surgery

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“…Not only massive deformity of the jaws, but also respiratory difficulty with maxillary involvement may be encountered in the severe forms of the disease. 22 Silva et al reported a case of an 8-year-old boy who presented with severe cherubism in which the lesions progressed rapidly; 23 17 months later he died due to pulmonary and gastrointestinal infections.…”

Section: Discussionmentioning

confidence: 99%