An extremely rare case of metastatic retinoblastoma of parotids presenting as a massive swelling in a child

Purkayastha, Abhishek; Sharma, Neelam; Pathak, Abhishek; Kapur, Bhupendra Nath; Dutta, Vibha

doi:10.21037/tp.2016.02.01

Cited by 8 publications

(7 citation statements)

References 13 publications

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“…Five cases achieved CR, one cases achieved PR, one case died, one case lost to follow-up, one additional case was undergoing treatment. These findings suggest that systemic intravenous chemotherapy is effective for metastatic RB; moreover, focal lesions (e.g., parotid gland and cervical lymph node involvement) can undergo combined treatment with surgery and radiotherapy, consistent with previous reports [12,16] . One patient who was failed to achieve complete remission by chemotherapy alone, underwent ASCT after systemic chemotherapy; the tumor achieved CR and the patient's condition was stable, suggesting that metastatic RB may benefit from chemotherapy combined with HSCT.…”

Section: Discussionsupporting

confidence: 91%

Nine cases of recurrence and metastasis of retinoblastoma with stable primary tumors

Li,

Huang,

Wang

et al. 2024

Preprint

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Purpose: To investigate the clinical characteristics, treatment, and outcomes of metastatic and recurrent retinoblastoma in patients with stable primary tumors. Methods: Clinical data were reviewed for nine patients (two boys and seven girls; median age, 23 months) with stable primary tumors who exhibited metastatic and recurrent retinoblastoma. All patients were treated in the Pediatrics Department of our hospital in the past 5 years. The clinical characteristics, treatment methods, and patient prognoses were recorded. Results: Of the nine patients, three had binocular disease and six had monocular disease (n=12 eyes in this study). The median interval between the end of initial treatment and onset of recurrence was 12 months (range, 3–96 months). Of the nine patients, primary tumors were proved to be stable, seven had bone metastasis, five had lymph node metastasis, two had parotid gland involvement, and three had bone marrow infiltration. At the end of the study period, one patient was lost to follow-up, one patient died, seven patients were alive and three of them were in complete remission and survived disease-free until the end of follow-up. In December 2020, the median overall survival after onset was 32.0 months (range, 18–155 months); the median overall survival after recurrence was 18.0 months (range, 5–34 months). Conclusions: Recurrent and metastatic retinoblastomas are uncommon and easily misdiagnosed at an early stage in patients with stable primary tumors. These cancers can be effectively treated using systemic intravenous chemotherapy combined with surgery, radiotherapy, and hematopoietic stem cell transplantation.

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Section: Discussionsupporting

confidence: 91%

Nine cases of recurrence and metastasis of retinoblastoma with stable primary tumors

Li,

Huang,

Wang

et al. 2024

Preprint

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“…Our case shows a large intraparotid mass which has extended to the submandibular level. There have only been five previously reported cases of retinoblastoma metastasizing to parotids [ 19 – 22 ]. Soni et al [ 19 ] reported the first ever case in 1978, and our case is the sixth such case reported to date.…”

Section: Discussionmentioning

confidence: 99%

Metastatic retinoblastoma of the parotid and submandibular glands: a rare case report

Wang

Zhang

et al. 2017

BMC Ophthalmol

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BackgroundRetinoblastoma is the most common intraocular malignancy occurring in children. It can metastasize to the regional lymph nodes, central nervous system and distant organs usually the bones and bone marrow and very rarely to the soft tissue. Here, we report a case of unilateral retinoblastoma in a 4-year-old girl accompanied by a large metastasis of the parotid and submandibular glands that developed about 6 months previously and gradually increased in size 5 months after enucleation of the left eye.Case presentationA 4-year-old girl with a history of unilateral retinoblastoma presented with a large, painful and worsening mass (about 20 × 23 cm) of the left side of the neck. Following surgery, the orbital tumour was completely resected, and the large tumour invasion range in the left side of the neck was not resected completely. Histopathological examination revealed retinoblastoma of the orbit and the parotid and submandibular glands. After chemotherapy and additional local radiotherapy on the parotid and submandibular glands, the tumour was inactive and stable.ConclusionsDelayed detection and inappropriate management contribute to poor outcomes. Fundus examinations, education regarding the early signs of RB, and optimization of the therapeutic strategy for RB may play important roles in ocular health.

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“…Combined systemic IVC and radiation therapy has been successful in treating soft tissue, bone, and CNS metastases in several small-scale studies [9,[16][17][18][19]. We recommend a comprehensive management plan and personalized treatment for metastatic RB.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of patients with recurrent retinoblastoma: a survival analysis

Li,

Wang,

Zhang

et al. 2024

BMC Cancer

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Background Management guidelines and corresponding survival data for patients with recurrent retinoblastoma (RB) are lacking. This study aimed to summarize the clinical characteristics of patients with recurrent RB and analyze their survival outcomes. Methods We retrospectively analyzed 68 patients with recurrent RB who underwent treatment in our institution from January 2016 to December 2020. Patients were grouped according to location of recurrence: intraocular, orbital, and distant metastasis. Results The male:female ratio was 1.3:1 and the median age at recurrence was 37.5 months (range, 30.3–62.8). The number of patients in the intraocular recurrence, orbital recurrence, and metastasis groups was 13 (19.1%), 23 (33.8%), and 32 (47.1%), respectively. Thirty patients died, 36 were alive at last follow-up, and two were lost to follow-up. Eye enucleation was performed in 94.1% of patients. Five-year overall survival in patients with intraocular recurrence, orbital recurrence, and metastasis was 84.6%, 69.6%, and 31.3%, respectively (P = 0.001). Most deaths occurred within 2 years of recurrence. Presence of high-risk pathological factors, central nervous system invasion, and absence of combination therapy were independent predictors of worse 5-year overall survival. Conclusion The rate of eye preservation in survivors of recurrent RB was very low. Although 5-year overall survival in patients who underwent treatment for intraocular and orbital recurrence was high, it was low in those with metastasis. RB patients may need lifelong follow-up for recurrence and secondary malignancy.

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An extremely rare case of metastatic retinoblastoma of parotids presenting as a massive swelling in a child

Cited by 8 publications

References 13 publications

Nine cases of recurrence and metastasis of retinoblastoma with stable primary tumors

Nine cases of recurrence and metastasis of retinoblastoma with stable primary tumors

Metastatic retinoblastoma of the parotid and submandibular glands: a rare case report

Characteristics of patients with recurrent retinoblastoma: a survival analysis

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