An Extremely Rare Case of a Primary Pancreatic Yolk Sac Tumor

Galanis, Ilias; Floros, Georgios; Simou, Magdalini; Kyriakopoulos, Georgios; Stylianidis, Georgios

doi:10.7759/cureus.26007

Cited by 2 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tumor showed partial positivity for AFP, Sall4, glypican-3, and cytokeratin 7, as found in our case, while MNF-116 and PLAP staining results were not described. The third was in a 33-year-old man with a solitary pancreatic head mass with obstructive jaundice ( 19 ). The patient had undergone Whipple’s procedure followed by cisplatin-based chemotherapy, resulting in at least 5 years of disease remission.…”

Section: Discussionmentioning

confidence: 99%

Cushing’s syndrome caused by ACTH precursors secreted from a pancreatic yolk sac tumor in an adult—a case report and literature review

Chang,

Woo,

Chow

et al. 2023

Front. Med.

View full text Add to dashboard Cite

Here, we report the first adult case of pancreatic yolk sac tumor with ectopic adrenocorticotropic hormone (ACTH) syndrome. The patient was a 27-year-old woman presenting with abdominal distension, Cushingoid features, and hyperpigmentation. Endogenous Cushing’s syndrome was biochemically confirmed. The ACTH level was in the normal range, which raised the suspicion of ACTH precursor-dependent disease. Elevated ACTH precursors were detected, supporting the diagnosis of ectopic ACTH syndrome. Functional imaging followed by tissue sampling revealed a pancreatic yolk sac tumor. The final diagnosis was Cushing’s syndrome due to a yolk sac tumor. The patient received a steroidogenesis inhibitor and subsequent bilateral adrenalectomy for control of hypercortisolism. Her yolk sac tumor was treated with chemotherapy and targeted therapy. Cushing’s syndrome secondary to a yolk sac tumor is extremely rare. This case illustrated the utility of ACTH precursor measurement in confirming an ACTH-related pathology and distinguishing an ectopic from a pituitary source for Cushing’s syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

Cushing’s syndrome caused by ACTH precursors secreted from a pancreatic yolk sac tumor in an adult—a case report and literature review

Chang,

Woo,

Chow

et al. 2023

Front. Med.

View full text Add to dashboard Cite

show abstract

“…There are several different types of tumors that make up GCTs, with teratomas being the most prevalent and endodermal sinus tumor (EST)/yolk sac tumor being the most frequently occurring malignant form [7] . The likelihood of GCTs in the pancreatic head region is very low, with only 3 reported cases of primary endodermal sinus tumor in the literature till date [7] , [18] ]. In this article, we discuss a EGCT case that proved to be an endodermal sinus tumor (EST).…”

Section: Introductionmentioning

confidence: 99%