An extremely rich repertoire of bursting patterns during the development of cortical cultures

Wagenaar, Daniel A.; Pine, J.; Potter, Steve M.

doi:10.1186/1471-2202-7-11

Cited by 710 publications

(700 citation statements)

References 33 publications

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“…Activity in acute slices and neuronal cultures is typically characterized by brief bursts of activity lasting tens of milliseconds (Corner et al 2002;Wagenaar et al 2006), separated by periods of quiescence lasting several seconds (figures 1 and 2). This activity is similar in many respects to that seen in slabs of cortex from in vivo animals that have been isolated from surrounding tissue (Timofeev et al 2000).…”

Section: Methodsmentioning

confidence: 99%

The criticality hypothesis: how local cortical networks might optimize information processing

Beggs

2007

Phil. Trans. R. Soc. A.

434

408

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Early theoretical and simulation work independently undertaken by Packard, Langton and Kauffman suggested that adaptability and computational power would be optimized in systems at the 'edge of chaos', at a critical point in a phase transition between total randomness and boring order. This provocative hypothesis has received much attention, but biological experiments supporting it have been relatively few. Here, we review recent experiments on networks of cortical neurons, showing that they appear to be operating near the critical point. Simulation studies capture the main features of these data and suggest that criticality may allow cortical networks to optimize information processing. These simulations lead to predictions that could be tested in the near future, possibly providing further experimental evidence for the criticality hypothesis.

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Section: Methodsmentioning

confidence: 99%

The criticality hypothesis: how local cortical networks might optimize information processing

Beggs

2007

Phil. Trans. R. Soc. A.

434

408

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“…This membrane provides a tight seal and is permeable to CO 2 and O 2 and largely impermeable to water vapor. Experiments from at least 10 different networks plated onto MEAs were performed on a heated microscope stage at 37 o C for 20 minutes at 18 days in vitro, a time point during development in which the network displayed vigorous electrical activity and for which network connectivity is established [30][31][32].…”

Section: B Electrophysiological Recordingsmentioning

confidence: 99%

Observed network dynamics from altering the balance between excitatory and inhibitory neurons in cultured networks

Chen

Dzakpasu

2010

Phys. Rev. E

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Complexity in the temporal organization of neural systems may be a reflection of the diversity of their neural constituents. These constituents, excitatory and inhibitory neurons, comprise a well-defined ratio in vivo and form the substrate for rhythmic oscillatory activity. To begin to elucidate the dynamical implications that underlie this balance, we construct novel neural circuits not ordinarily found in nature and study the resulting temporal patterns. We culture several networks of neurons composed of varying fractions of excitatory and inhibitory cells and use a multi-electrode array to study their temporal dynamics as this balance is modulated. We use the electrode burst as the temporal imprimatur to signify the presence of network activity. Burst durations, inter-burst intervals, and the number of spikes participating within a burst are used to illustrate the vivid differences in the temporal organization between the various cultured networks. When the network consists largely of excitatory neurons, no network temporal structure is apparent. However, the addition of inhibitory neurons evokes a temporal order. Calculation of the temporal autocorrelation shows that when the number of inhibitory neurons is a major fraction of the network, a striking network pattern materializes when none was previously present.

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“…Our approach can be readily extended to highly integrated systems, offering a unique advantage over previous works with microfabricated planar FETs and microelectrodes [75,76]. For example, we designed and fabricated a repeating structure that consists of 50 addressable NW elements per neuron, as shown in Fig.…”

Section: Hybrid Nw-neuron Interfacesmentioning

confidence: 99%

Assembly and integration of semiconductor nanowires for functional nanosystems

Lieber

2010

Pure and Applied Chemistry

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Central to the bottom-up paradigm of nanoscience, which could lead to entirely new and highly integrated functional nanosystems, is the development of effective assembly methods that enable hierarchical organization of nanoscale building blocks over large areas. Semiconductor nanowires (NWs) represent one of the most powerful and versatile classes of synthetically tunable nanoscale building blocks for studies of the fundamental physical properties of nanostructures and the assembly of a wide range of functional nanoscale systems. In this article, we review several key advances in the recent development of general assembly approaches for organizing semiconductor NW building blocks into designed architectures, and the further integration of ordered structures to construct functional NW device arrays. We first introduce a series of rational assembly strategies to organize NWs into hierarchically ordered structures, with a focus on the blown bubble film (BBF) technique and chemically driven assembly. Next, we discuss significant advances in building integrated nano electronic systems based on the reproducible assembly of scalable NW crossbar arrays, such as high-density memory arrays and logic structures. Lastly, we describe unique applications of assembled NW device arrays for studying functional nanoelectronic-biological inter faces by building well-defined NW-cell/tissue hybrid junctions, including the highly integrated NW-neuron interface and the multiplexed, flexible NW-heart tissue interface.

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An extremely rich repertoire of bursting patterns during the development of cortical cultures

Cited by 710 publications

References 33 publications

The criticality hypothesis: how local cortical networks might optimize information processing

The criticality hypothesis: how local cortical networks might optimize information processing

Observed network dynamics from altering the balance between excitatory and inhibitory neurons in cultured networks

Assembly and integration of semiconductor nanowires for functional nanosystems

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