An Fe‐MIL100 Based Drug Delivery System for pH and Glutathione Dual‐Responsive Drug Release

Abstract

Fe-MIL100 with high Fe(II) content is synthesized at room temperature via a green synthesis process and used to form drug delivery system DOX@PEG-MIL100 by loading doxorubicin (DOX) and coating with polyethyleneglycol (PEG). This drug delivery system shows pH and glutathione (GSH) dualresponsive drug release behavior in response to tumor microenvironment and a high cytotoxicity in tumor cell line.