An fMRI study of “theory of mind” in at-risk states of psychosis: Comparison with manifest schizophrenia and healthy controls

Brüne, Martin; Özgürdal, Seza; Ansorge, Nina; Reventlow, H. Graf von; Peters, Sören; Nicolas, Volkmar; Tegenthoff, Martin; Juckel, Georg; Lissek, Silke

doi:10.1016/j.neuroimage.2010.12.018

Cited by 99 publications

(83 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the contrary, previous studies have found increased brain activation in individuals at-risk (prodromal) of developing schizophrenia [125] as well as individuals with psychosis proneness [126]. The former study was conducted in prodromal individuals for psychosis (n=10, mean age = 25.5 years) using the mental states attribution task presented using cartoons [125]. The results showed that prodromal individuals showed greater activation in the ToM neural network [including prefrontal cortex, the posterior cingulate and temporo-parietal cortex] than healthy controls.…”

Section: Neuroimaging Studies Of Theory Of Mind Deficits In Schizophrmentioning

confidence: 58%

“…The results showed that the brain activity in mPFC of schizophrenia patients increased after recovery compared to their acute episode [124]. On the contrary, previous studies have found increased brain activation in individuals at-risk (prodromal) of developing schizophrenia [125] as well as individuals with psychosis proneness [126]. The former study was conducted in prodromal individuals for psychosis (n=10, mean age = 25.5 years) using the mental states attribution task presented using cartoons [125].…”

Section: Neuroimaging Studies Of Theory Of Mind Deficits In Schizophrmentioning

confidence: 89%

See 1 more Smart Citation

Theory of Mind in the Early Course of Schizophrenia

Vyas

et al. 2017

CPSR

View full text Add to dashboard Cite

Theory of mind deficit is a core feature of schizophrenia and is considered a vulnerability marker of the disorder. The majority of studies measuring theory of mind in schizophrenia involve multiple-episode or chronic schizophrenia patients, and therefore it is important to delineate whether these deficits occur before or following illness-onset by assessing high-risk subjects (clinical high risk and ultra-high risk), early-onset psychosis, and first-degree relatives. We address the question of whether theory of mind impairment is specific or a facet of general cognitive impairment in these clinical populations, and incorporate genetic and neuroimaging studies on theory of mind. The review provides a succinct evaluation of the literature, discusses current limitations and proposes future directions.

show abstract

Section: Neuroimaging Studies Of Theory Of Mind Deficits In Schizophrmentioning

confidence: 58%

Section: Neuroimaging Studies Of Theory Of Mind Deficits In Schizophrmentioning

confidence: 89%

Theory of Mind in the Early Course of Schizophrenia

Vyas

et al. 2017

CPSR

View full text Add to dashboard Cite

show abstract

“…Theory of Mind (ToM) or mentalizing, a subdomain of social cognition, is defined as the ability to think about people in terms of their mental states (Green et al, 2008a). The bulk of evidence has shown consistent social cognitive impairments in schizophrenia (Green et al,2008b), that can be present at early phases (Brüne et al, 2011;Chung et al, 2008;Couture et al, 2008) and persist trough different phases of the illness (Green et al, 2011), and several reviews and meta-analysis have established that patient-control differences on mentalizing skills are large and persistent across the chronic phase of illness (Bora et al, 2009;Brüne 2005). Clozapine is the only antipsychotic that has been found to show superior efficacy for treatment-resistant patients when compared to conventional and atypical antipsychotic drugs.…”

Section: Introductionmentioning

confidence: 99%

Mentalizing Skills Deficits in Schizophrenia as a Clue for Drug Choice: Clozapine Versus Other Antipsychotics on Keeping Outpatients Stable

Duñó¹,

Langohr²,

Palao³

et al. 2012

Mental Illnesses - Understanding, Prediction and Control

View full text Add to dashboard Cite

“…Metacognitive abilities are thought to be represented in an extended neural network comprising cortical midline structures, in particular the medial frontal cortex (mPFC), the anterior cingulate cortex (ACC), the precuneus, as well as lateral areas of the middle temporal lobes (MTL), the temporoparietal junction (TPJ), the superior temporal sulcus (STS) and the temporal poles (reviewed in [17][18][19][20]. The area extending from the ACC to the anterior frontal pole, particularly the paracingulate cortex, is supposed to be engaged in self-reflection, person perception and in making inferences about others' thoughts (17).…”

Section: Introductionmentioning

confidence: 99%

“…The area extending from the ACC to the anterior frontal pole, particularly the paracingulate cortex, is supposed to be engaged in self-reflection, person perception and in making inferences about others' thoughts (17). The mPFC and the ACC are also involved in distinguishing self from non-self, in error monitoring, and in differentiating salient from nonsalient stimuli (21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

From social neurons to social cognition: implications for schizophrenia research / Sosyal nöronlardan sosyal kognisyona: Şizofreni araştırmalarına etkileri

Brüne¹,

Ebert²

2011

Dusunen Adam

Self Cite

View full text Add to dashboard Cite

From social neurons to social cognition: implications for schizophrenia researchThe term schizophrenia embraces a group of disorders that are characterised by a heterogeneous set of symptoms. Poor social cognition, including metacognitive dysfunction is present across all schizophrenia phenotypes, accounting for a large proportion of patients' social impairment. Metacognitive functioning is subserved by a distinct neural network of widely distributed regions of the brain, foremost areas of the prefrontal cortex, as well as, areas in the temporal and parietal lobes. While dysfunction of the metacognition neural network in schizophrenia has been well documented, the underlying neuronal correlates are only partially understood. This review focuses on two distinct cell populations that evolved during primate evolution: The mirror neurons, and the von Economo neurons. Empirical evidence suggests that these cell types have a special role in social cognition and metacognitive functioning. However, only recent studies have addressed their potential role in schizophrenia. In spite of current paucity of research on mirror neuron function in schizophrenia, it seems plausible to suggest that their functional properties are compromised, and contribute to aberrant imitation behaviour in schizophrenia. The potential impact of von Economo neurons in the pathophysiology of schizophrenia is even less clear, but future research may help to better understand the nature of this devastating group of disorders. Key words: Schizophrenia, cognition, metacognitive, metacognition, theory of mind ÖZET Sosyal nöronlardan sosyal kognisyona: Şizofreni araştırmalarına etkileriŞizofreni terimi, heterojen belirtilerle karakterize bir hastalık grubunu kapsar. Hastaların sosyal kaybının önem-li bir bölümünden sorumlu olan metakognitif işlev bozukluğunu da kapsayan kötü sosyal biliş, tüm şizofreni fenotiplerinde vardır. Metakognitif işlevsellik, temporal ve parietal loblardaki alanlar kadar prefrontal korteksin önemli alanları gibi beynin birçok bölgesine yaygın şekilde dağılan ayrı bir sinir ağı ile desteklenmektedir. Şizofrenideki metakognisyon sinir ağındaki işlev bozukluğu daha önceden iyi tanımlanmış olmakla birlikte, altta yatan sinirsel bağlantılar yalnızca kısmen anlaşılabilmiştir. Bu gözden geçirme, primat evrimi boyunca gelişen iki ayrı hücre popülasyonuna odaklanmıştır: ayna nöronlar ve von Economo nöronları. Ampirik kanıtlar bize, bu hücre tiplerinin sosyal biliş ve metakognitif işlevsellik konusunda özel bir rolü olduğunu düşündürt-mektedir. Bununla birlikte, sadece yakın zamandaki çalışmalar bunların şizofrenideki potansiyel rollerini tanım-layabilmiştir. Ayna nöron işlevlerine yönelik araştırmaların bazı eksikliklerine rağmen, bunların işlevsel özellikle-rinin etkilendiği ve şizofrenideki anormal taklit davranışına katkıda bulunduğu fikri akla yatkın görünüyor. Şizof-reninin patofizyolojisinde yer alan von Economo nöronlarının potansiyel etkisi hala yeterince açık değildir, fakat gelecek araştırmalar, belki bu yıkıcı hastalık...

show abstract

An fMRI study of “theory of mind” in at-risk states of psychosis: Comparison with manifest schizophrenia and healthy controls

Cited by 99 publications

References 50 publications

Theory of Mind in the Early Course of Schizophrenia

Theory of Mind in the Early Course of Schizophrenia

Mentalizing Skills Deficits in Schizophrenia as a Clue for Drug Choice: Clozapine Versus Other Antipsychotics on Keeping Outpatients Stable

From social neurons to social cognition: implications for schizophrenia research / Sosyal nöronlardan sosyal kognisyona: Şizofreni araştırmalarına etkileri

Contact Info

Product

Resources

About