An fMRI study of theory of mind in schizophrenic patients with “passivity” symptoms

Brüne, Martin; Lissek, Silke; Fuchs, N; Witthaus, Henning; Peters, Sören; Nicolas, Volkmar; Juckel, Georg; Tegenthoff, Martin

doi:10.1016/j.neuropsychologia.2008.01.023

Cited by 126 publications

(77 citation statements)

References 41 publications

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“…When undertaking theory of mind tasks, patients with schizophrenia and passivity symptoms show reduced activation of the right insula and anterior cingulate. 116 Positron emission tomography and fMRI studies have also found abnormalities in the activation of the insula in addition to brain regions involved in action monitoring in patients with passivity symptoms. 117,118 Consistent with a study by Crespo-Facorro and colleagues, 22 a recent study from our group has shown significant correlation between the volume of the salience network and severity of delusions and hallucinations.…”

Section: Correlation Of Insular Deficits With Clinical Symptomsmentioning

confidence: 99%

Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction

Palaniyappan

Liddle

2012

jpn

496

443

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Section: Correlation Of Insular Deficits With Clinical Symptomsmentioning

confidence: 99%

Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction

Palaniyappan

Liddle

2012

jpn

496

443

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“…A number of functional brain imaging studies have demonstrated that several brain regions including cortical midline structures, the temporo-parietal junction, the inferior frontal gyrus, as well as parts of the greater limbic lobe, i.e. the ACC and the FI, not only subserve several of the above-mentioned complex metacognitive abilities, but also, that these regions seem to be involved in the pathophysiology of schizophrenia (34)(35)(36)(37)(38). Neuroanatomically, these brain areas are highly interesting, because they contain two evolutionarily novel cell types that may play a role in metacognition.…”

Section: Discussionmentioning

confidence: 99%

“…In a similar vein, Lee and colleagues (36) found that patients with acute episodes activated areas in the left mPFC to a lesser degree compared with healthy control subjects in a paradigm that required empathic responses. Similarly, Brüne et al (37) studied metacognition in patients with schizophrenia who experienced "passivity" symptoms. They found that patients displayed a markedly diverging pattern of brain activation during performance compared with healthy controls in that the patient group showed significantly less activation of the right anterior cingulate cortex (ACC) and right insula compared with controls, but greater activation in dorsal areas of the medial prefrontal cortex, right temporal areas and left temporoparietal junction.…”

Section: Introductionmentioning

confidence: 99%

From social neurons to social cognition: implications for schizophrenia research / Sosyal nöronlardan sosyal kognisyona: Şizofreni araştırmalarına etkileri

Brüne¹,

Ebert²

2011

Dusunen Adam

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From social neurons to social cognition: implications for schizophrenia researchThe term schizophrenia embraces a group of disorders that are characterised by a heterogeneous set of symptoms. Poor social cognition, including metacognitive dysfunction is present across all schizophrenia phenotypes, accounting for a large proportion of patients' social impairment. Metacognitive functioning is subserved by a distinct neural network of widely distributed regions of the brain, foremost areas of the prefrontal cortex, as well as, areas in the temporal and parietal lobes. While dysfunction of the metacognition neural network in schizophrenia has been well documented, the underlying neuronal correlates are only partially understood. This review focuses on two distinct cell populations that evolved during primate evolution: The mirror neurons, and the von Economo neurons. Empirical evidence suggests that these cell types have a special role in social cognition and metacognitive functioning. However, only recent studies have addressed their potential role in schizophrenia. In spite of current paucity of research on mirror neuron function in schizophrenia, it seems plausible to suggest that their functional properties are compromised, and contribute to aberrant imitation behaviour in schizophrenia. The potential impact of von Economo neurons in the pathophysiology of schizophrenia is even less clear, but future research may help to better understand the nature of this devastating group of disorders. Key words: Schizophrenia, cognition, metacognitive, metacognition, theory of mind ÖZET Sosyal nöronlardan sosyal kognisyona: Şizofreni araştırmalarına etkileriŞizofreni terimi, heterojen belirtilerle karakterize bir hastalık grubunu kapsar. Hastaların sosyal kaybının önem-li bir bölümünden sorumlu olan metakognitif işlev bozukluğunu da kapsayan kötü sosyal biliş, tüm şizofreni fenotiplerinde vardır. Metakognitif işlevsellik, temporal ve parietal loblardaki alanlar kadar prefrontal korteksin önemli alanları gibi beynin birçok bölgesine yaygın şekilde dağılan ayrı bir sinir ağı ile desteklenmektedir. Şizofrenideki metakognisyon sinir ağındaki işlev bozukluğu daha önceden iyi tanımlanmış olmakla birlikte, altta yatan sinirsel bağlantılar yalnızca kısmen anlaşılabilmiştir. Bu gözden geçirme, primat evrimi boyunca gelişen iki ayrı hücre popülasyonuna odaklanmıştır: ayna nöronlar ve von Economo nöronları. Ampirik kanıtlar bize, bu hücre tiplerinin sosyal biliş ve metakognitif işlevsellik konusunda özel bir rolü olduğunu düşündürt-mektedir. Bununla birlikte, sadece yakın zamandaki çalışmalar bunların şizofrenideki potansiyel rollerini tanım-layabilmiştir. Ayna nöron işlevlerine yönelik araştırmaların bazı eksikliklerine rağmen, bunların işlevsel özellikle-rinin etkilendiği ve şizofrenideki anormal taklit davranışına katkıda bulunduğu fikri akla yatkın görünüyor. Şizof-reninin patofizyolojisinde yer alan von Economo nöronlarının potansiyel etkisi hala yeterince açık değildir, fakat gelecek araştırmalar, belki bu yıkıcı hastalık...

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“…Most studies describe lower activation of the core mentalizing system and impaired mentalizing ability in behavioral tasks [33][34][35]. A few studies found increased activation of brain regions associated with mentalizing [36,37] leading to the hypothesis that individuals with schizophrenia may need greater activation in these regions to achieve the same level of mentalizing proficiency, suggesting neural inefficiency. It was proposed that positive symptoms are linked to hypermentalizing and negative symptoms to hypomentalizing; positive symptoms should result in a pattern of additional emotion and intention attributions to other people, while negative symptoms should result in a lack of emotion and intention attributions [38].…”

Section: Mentalizingmentioning

confidence: 99%

Untitled

2016

IJCNMH

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Although functional recovery could be advocated as an achievable treatment goal, many effective interventions for the treatment of psychotic symptoms, such as antipsychotic drugs, may not improve functioning. The last two decades of cognitive and clinical research on schizophrenia were a turning point for the firm acknowledgment of how relevant social cognitive deficits and negative symptoms could be in predicting psychosocial functioning. The relevance of social cognition dysfunction in schizophrenia patients' daily living is now unabated. In fact, social cognition deficits could be the most significant predictor of functionality in patients with schizophrenia, non-redundantly with neurocognition. Emerging evidence suggests that negative symptoms appear to play an indirect role, mediating the relationship between neurocognition and social cognition with functional outcomes. Further explorations of this mediating role of negative symptoms have revealed that motivational deficits appear to be particularly important in explaining the relationship between both neurocognitive and social cognitive dysfunction and functional outcomes in schizophrenia. In this paper we will address the relative contribution of two key constructs-social cognitive deficits and negative symptoms, namely how intertwined they could be in daily life functioning of patients with schizophrenia.

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An fMRI study of theory of mind in schizophrenic patients with “passivity” symptoms

Cited by 126 publications

References 41 publications

Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction

Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction

From social neurons to social cognition: implications for schizophrenia research / Sosyal nöronlardan sosyal kognisyona: Şizofreni araştırmalarına etkileri

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