An HII liquid crystal-based delivery system for cyclosporin A: Physical characterization

Recent Developments in Lyotropic Liquid Crystals as Drug Delivery Vehicles

“…On the macroscopic level, this was correlated with the improvement of elastic properties and thermal stability of the H II mesophase (Libster et al, 2007 ). Structural fl exibility and stability is essential for a drug delivery system, especially for tuning its physical properties (such as viscosity) and composition.…”

“…This enabled expanding conditions to obtain stable H II mesophases at room temperature. In addition, it was shown that phosphatidylcholine (PC) can be embedded into the ternary GMO -TAG -water system (Ben Ishai et al, 2009 ;Libster et al, 2007Libster et al, , 2008Libster et al, , 2009a. PC was incorporated into the ternary mesophases because it is known that phospholipid -based structures possess relatively high thermal stability and enhance transdermal drug permeation (Kurosaki et al, 1991 ;Touitou et al, 1994 ;Spernath and Aserin, 2006 ) and transmembrane transport across the digestive tract (Brondsted et al, 1995 ;Liu et al, 1999 ).…”

“…Fractal analysis indicated that the mesoscale topography of the H II phase was likely to be infl uenced by the microstructural parameters and the water content of the samples (Libster et al, 2008 ). Garti and coworkers also made considerable progress elucidating the solubilization of therapeutic peptides into the H II mesophase (Cohen -Avrahami et al, 2010 ;Libster et al, 2007Libster et al, , 2009aMishraki et al, 2010a,b ).…”

“…Libster and co -workers explored and controlled the physical properties of H II mesophases to use these systems as drug delivery vehicles for biologically active peptides and proteins. The results of this structural research enabled signifi cant expansion of the application spectrum of hexagonal LLCs, utilizing them for the solubilization of peptides and proteins (Libster et al, 2007(Libster et al, , 2009a(Libster et al, ,b, 2011, into this mesophase and its utilization as sustained drug delivery vehicle. Two model cyclic peptides, cyclosporin A (11 amino acids) and desmopressin (9 amino acids), of similar molecular weight but with very different hydrophilic and lipophilic properties, were chosen to demonstrate the feasibility of using the H II mesophase .…”

Nanostructured reverse hexagonal liquid crystals sustain plasma concentrations for a poorly water-soluble drug after oral administration

“…The use of V 2 and H 2 phases as drug delivery carriers for various routes of administration in the form of bulk systems and as cubosomes or hexosomes has been proposed [11][12][13][14][15][16][17][18]. Several studies have examined the use of liquid-crystalline carriers as oral delivery systems in vitro using glyceryl monooleate (GMO) systems [19][20][21]; however, there are few examples in the literature where in vivo sustained release performance has been reported.…”