An HLA class II locus, previously identified by a genome-wide association study, is also associated with susceptibility to pulmonary tuberculosis in a Chinese population

Miao, Ruifen; Huang, Shuran; Li, Chen; Ding, Songning; Wang, Rong; Xu, Ke; Yang, Chen; Xu, Fei; Ge, Haibo

doi:10.1016/j.meegid.2018.06.022

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…A GWAS by Zheng et al [36] reported that 2 loci 14q24.3 (rs12437118, Pcombined = 1.72 × 10−11, OR = 1.277, ESRRB) and 20p13(rs6114027, Pcombined = 2.37 × 10.11, OR = 1.339, TGM6) were significantly associated with TB in Han Chinese individuals. Miao et al [37] reported that rs9272461 is significantly associated with the risk of PTB in various genetic models. Hence, GWAS are required to further validate the present results.…”

Section: Discussionmentioning

confidence: 99%

3’UTR polymorphisms in NRAMP1 are associated with the susceptibility to pulmonary tuberculosis: A MOOSE-compliant meta-analysis

et al. 2019

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Many studies have investigated the association between the 3’UTR polymorphism in natural resistance-associated macrophage protein 1 ( NRAMP1 ) and the risk of pulmonary tuberculosis (PTB), Revealing inconclusive results. This study aimed to investigate the correlation between the NRAMP1 3’UTR polymorphism and the risk of PTB. This meta-analysis included 29 case–control studies to better and comprehensively assess this correlation. Pooled odds ratios (ORs) and 95% confidence interval (95% CIs) were calculated to assess the strength of the association. These 29 case–control studies included 4672 cases and 6177 controls. The NRAMP1 3’UTR polymorphism displayed a significant positive correlation with the risk of PTB in 3 models (for del/del vs ins/ins: OR = 1.22, 95% CI = 1.01–1.47; for Ins/del vs ins/ins: OR = 1.19, 95% CI 1.08–1.30; for Ins/del + del/del vs ins/ins: OR = 1.25, 95% CI = 1.08–1.45). A stratified analysis by ethnicity revealed that the NRAMP1 3’UTR polymorphism was associated with an increased risk of PTB in the Asian population, but not in Caucasian, African, and South American populations. The present results indicate that the NRAMP1 3’UTR polymorphism may be considered a risk factor for PTB in the Asian population.

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Section: Discussionmentioning

confidence: 99%

3’UTR polymorphisms in NRAMP1 are associated with the susceptibility to pulmonary tuberculosis: A MOOSE-compliant meta-analysis

et al. 2019

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“…Similarly, there is substantial evidence that variations in the HLA class I and II genes could determine the outcome of MTB infection (Saraav et al, ; Toyo‐Oka et al, ). A case–control study in Chinese Han population verified that HLA class II locus rs9272461 affects the susceptibility to pulmonary TB (PTB) (Miao et al, ). Moreover, a study showed that HLA‐DR + CD4 + T cells may contribute to disease‐associated inflammation by compromising regulatory T cells‐mediated suppression in PTB (Ahmed et al, ).…”

Section: Introductionmentioning

confidence: 99%

Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population

Wang

Cao

Zhang

et al. 2019

Molec Gen & Gen Med

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Background Tuberculosis (TB) is the second‐leading cause of death globally. Genetic polymorphisms in human leukocyte antigens (HLA)‐DQB2, HLA‐DPA1, and HLA‐DPB1 may partly explain individual differences in TB susceptibility. Methods We performed a hospital‐based case–control study to assess the genetic influence of single‐nucleotide polymorphisms (SNPs) in the HLA (HLA‐DPA, HLA‐DPB, and HLA‐DQB) on the development of TB. There were 248 TB‐infected cases and 340 healthy controls in this study. Results The HLA‐DQB2 rs7453920 genotype GG was applied as the reference group, the GA genotype was related to a considerably magnified risk of TB (GA vs. GG: adjusted OR = 1.547, 95% CI = 1.039–2.304, p = 0.032). Nevertheless, the other two SNPs were not associated with TB risk. Stratified analyses suggested that tobacco was associated with an increased risk of TB in HLA‐DQB2 rs7453920 G>A. Conclusion These results suggested that the functional HLA‐DQB2 rs7453920 G>A polymorphism may contribute to the genetic susceptibility to TB. Nevertheless, the results were based on a limited sample size, and larger well‐designed studies are expected to confirm these preliminary findings.

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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Wong¹,

Zhang²,

Hsiung³

et al. 2020

Genomics

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An HLA class II locus, previously identified by a genome-wide association study, is also associated with susceptibility to pulmonary tuberculosis in a Chinese population

Cited by 5 publications

References 17 publications

3’UTR polymorphisms in NRAMP1 are associated with the susceptibility to pulmonary tuberculosis: A MOOSE-compliant meta-analysis

3’UTR polymorphisms in NRAMP1 are associated with the susceptibility to pulmonary tuberculosis: A MOOSE-compliant meta-analysis

Association of human leukocyte antigens‐DQB2/DPA1/DPB1 polymorphism and pulmonary tuberculosis in the Chinese Uygur population

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

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