“…The HPLC-UV (Wong and Charles, 1995) method is unsuitable for the measurement of lisinopril in plasma where the drug concentrations are rather low. The HPLC-F (Sagirli and Ersoy, 2004;El-Amam et al, 2004) and GC-MS (Leis et al, 1998(Leis et al, , 1999 methods require derivatization of lisinopril to produce a chromophore detectable by fluorescence or to covert the thermo labile and ionic lisinopril into a derivative that is suitable for gas chromatography analysis. Although the HPLC-MS (Tsakalof et al, 2003) was successfully applied to the determination of lisinopril in human plasma, the lower limit of quantification (LLOQ) in plasma of the method was 6 ng/mL, which was insufficiently sensitive to enable full pharmacokinetic profiling of lisinopril in low dosages.…”