Possible roles of point defect clustering in the formation of deformation twins in 7-TiAI are critically assessed by reviewing the available models of dislocation-assisted twin nucleation and experimental data on deformation twinning in Ti-56 at.% A1 single crystals and two-phase Ti-47 at.% A1 alloys. According to the pole mechanism for twinning in the Llo structure, a reasonable combination of the stress concentration (n-~ 27) and the vacancy supersaturation (c/c,~ 13) is needed to overcome the critical stages of twin formation. The so-called radiation-induced ductility reported in Ti-47 at.% A1 alloys is attributed to the effective formation of twin embryos in the presence of interstitial-type Frank loops and the subsequent nucleation and growth of twins during plastic deformation.