An <i>in vitro</i> analysis of the antimicrobial properties of 10 silver-containing dressings

Thomas, Stephen B.; McCubbin, Patrick E.

doi:10.12968/jowc.2003.12.8.26526

Cited by 102 publications

(74 citation statements)

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“…13,14 Algidex Ag is a foam pad coated with silver alginate in a maltodextrin matrix, and performed very well in its bactericidal effects and the duration of treatment when compared with other silvercontaining dressings. [15][16][17][18] The embedded silver is in an ionic state, providing for more rapid and continued release to the underlying tissue. The release of silver ions has been found to be at a fairly constant rate over a total of 10 d, although the pads are recommended to be changed after 7 d. 17 The safety of silver usage in both infants and adults has also been thoroughly investigated.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Tracheostomy Wound Healing Using Maltodextrin and Silver Alginate Compounds in Pediatrics: A Pilot Study

et al. 2014

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BACKGROUND: Tracheostomy wounds are commonly encountered in children but rarely reported. Relatively few treatments are available or have been investigated to manage this problem. Healing times for pediatric tracheostomy wounds are often unpredictable and protracted. Recent use of maltodextrin gel (MD) and a silver alginate sponge (AG) at our institution has demonstrated expedited healing and interest in this novel treatment for tracheostomy wounds. METHODS: We conducted an 11-month retrospective review of children with wound complications following tracheostomy placement at a tertiary care facility. Wounds were evaluated and rated based upon the National Pressure Ulcer Advisory Panel staging system. Subjects identified with stage 2 or greater tracheostomy-related ulcers treated with MD and/or AG were included. Subject characteristics and wound healing rates were tabulated in a database that included age, wound site, initial and final wound stage, type of treatment, length of treatment, and complications. Tracheostomy wounds treated as an out-patient were excluded from the study. RESULTS: Eighteen subjects, which included both in-patients and out-patients, were treated with AG and/or MD during the study period for tracheostomy-related wounds. Of the 26 subjects with tracheostomies performed during the study period, 10 (38.5%) were treated for postoperative wounds. A total of 11 subjects completed their in-patient wound treatment and were thus included in the study. Average subject age was 5.3 y (range 0.25-15.6 y). Wound locations were as follows: infrastomal region (n ‫؍‬ 8), stoma (n ‫؍‬ 2), and lateral neck (n ‫؍‬ 1). Six subjects had stage 2 wounds, 4 had stage 3 wounds, and 1 had a stage 4 ulcer. All wounds achieved complete epithelialization following treatment with MD and/or AG. The average length of treatment was 12.8 d (range 6 -28 d). No adverse effects were identified. CONCLUSIONS: Postoperative tracheostomy wounds are common. The use of MD and AG provides an effective and safe treatment for tracheostomy-related ulcers.

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Section: Discussionmentioning

confidence: 99%

Enhanced Tracheostomy Wound Healing Using Maltodextrin and Silver Alginate Compounds in Pediatrics: A Pilot Study

et al. 2014

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“…Studies, however, have failed to identify a correlation between the silver content of dressings and its antimicrobial effect, 51 or a correlation between silver release and antimicrobial effect. 52 However, the latter study 52 did not test both factors in the same test system and, because silver release depends on the test medium, this may account for the observed lack of correlation.…”

Section: Planktonic Microorganismsmentioning

confidence: 99%

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Davies

McCarty

Hamberg³

2017

J Wound Care

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Phil Davies has more than 25 years of experience of working in healthcare-related industries. During that time, he has authored and contributed to numerous peer-reviewed journal articles and conference presentations (oral and poster) relating to wound care and other areas of healthcare. Phil was awarded a BSc (Hons) Medical Cell Biology and Biochemistry by the University of Liverpool (United Kingdom) in 1989.Sara McCarty was awarded her BSc (Hons) in biomedical sciences in 2008 by the University of Chester, UK. Since then, Sara has gained research experience in the field of wound healing. As a medical writer, she has also authored and contributed to a number of peer-reviewed journal articles and conference presentations. In 2014, she was awarded a PhD in the role and control of matrix metalloproteases in cutaneous wound healing.Kristina Hamberg has over 10 years of experience of working with the design and development of wound care products, particularly those with antimicrobial properties. During that time, she has become an expert within the areas of microbiology and test method development, as well as infection prevention. Kristina was awarded her MSc in food science in 1997 from the University of Kalmar, Sweden, and in 2002 she was awarded a PhD for microbiological evaluation of novel technologies for food preservation by Chalmers Technical University, Gothenburg, Sweden.How to cite this document: Davies, P., McCarty, S., Hamberg, K. Silver-containing foam dressings with Safetac: a review of the scientific and clinical data. J Wound Care 2017; 26: 6 (Suppl. 1), S1-S32. Conclusion S24 References S27Downloaded from magonlinelibrary.com by 054

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“…At low chloride ion concentration Ag + inhibits the respiratory path of sensitive strain organisms, destroys the cell wall, impairs essential enzymes, obstructs metabolic activity and/or causes RNA and DNA alteration [17,18]. The investigations of the efficacies of silver ions as antimicrobial agents are usually carried out in vitro in a culture media [19][20][21].…”

Section: Action Of Silver On Microorganismsmentioning

confidence: 99%

Silver and its application as an antimicrobial agent

Melaiye¹,

Youngs²

2005

Expert Opinion on Therapeutic Patents

264

160

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This review summarises patents published from 2001 to 2004 on the microcidal properties of silver-releasing materials for healthcare and medicine. The anti-inflammatory, re-epitheliasation and antihaemorrhagic properties of the silver-releasing materials are also disclosed. A biological evaluation of the antiviral properties of silver tetra-silver tetra-oxide is discussed, but no biological data have been reported to support the claim that silver (I) has antiviral properties, as disclosed by most of the patents.

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An in vitro analysis of the antimicrobial properties of 10 silver-containing dressings

Abstract: The variation in the structure and properties of the many silver dressings now on the market might be expected to affect their antimicrobial properties. This study, which follows up a paper published last March, compares their performance.

Cited by 102 publications

References 1 publication

Enhanced Tracheostomy Wound Healing Using Maltodextrin and Silver Alginate Compounds in Pediatrics: A Pilot Study

Enhanced Tracheostomy Wound Healing Using Maltodextrin and Silver Alginate Compounds in Pediatrics: A Pilot Study

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Silver and its application as an antimicrobial agent

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