An <i>in vitro</i> examination of the antioxidant and anti-inflammatory properties of buckwheat honey

Berg, A. J. J. van den; Worm, Edwin van den; Ufford, H. C. Quarles van; Halkes, S.B.A.; Hoekstra, M.J.; Beukelman, C.J.

doi:10.12968/jowc.2008.17.4.28839

Cited by 139 publications

(87 citation statements)

References 28 publications

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“…It has been hypothesized that honey's healing effect on wounds of rodents and humans may in part be due to its antioxidant, antibacterial and anti-inflammatory effects (Van den Berg et al, 2008), based on the effect of honey or parts of its constituents on mediators of inflammation.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and anti-inflammatory activities of Apis mellifera honey on the Helicobacter pylori infection of Wistar rats gastric mucosa

et al. 2017

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Considering that Helicobacter pylori, a bacterium able to colonize the upper gastrointestinal tract and cause mucosal injury, not always can be effectively eradicated by the traditional approaches, there is an interest in alternative therapies until a vaccine be available. Honey is a food supplement with high carbohydrate content and antioxidant activity, as well as broad antimicrobial spectrum. After analyzing the physicochemical and in vitro antimicrobial properties of an Apis mellifera honey from the Atlantic forest of Alagoas / Brazil, the purpose of the present work was evaluate its in vivo effects against Helicobacter pylori in the gastric mucosa of Wistar rats. First, it was verified the success of inoculation/infection of the pathogen in the gastric mucosa of the rats, through the subsequent removal of their stomachs for histological analysis (hematoxylin and eosin stain and Giemsa stain). Then, four groups of animals were treated with sterilized distilled deionized water, the Apis mellifera honey, a combination of omeprazole, amoxicillin and clarithromycin, and an association of such medicines and honey (1:1). Except the control, all treatments were effective in combating infection, however, honey reduced the inflammatory process, whilst the antibiotics increase the number of eosinophils.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial and anti-inflammatory activities of Apis mellifera honey on the Helicobacter pylori infection of Wistar rats gastric mucosa

et al. 2017

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“…Leong et al (2011) reported that honey exhibited potent and dose-dependent reduction of human neutrophil superoxide anion production in vitro. Other groups also described a scavenger activity of honey on O ·− 2 using the xanthinexanthine oxidase system (Henriques et al 2006;Van den Berg et al 2008). Honey was also found to decrease the luminol-enhanced chemiluminescence in opsonized zymosan-stimulated whole blood and isolated leucocytes (Mesaik et al 2008).…”

Section: Discussionmentioning

confidence: 97%

Effect of honey on purified equine myeloperoxidase activity and superoxide radical production in activated Polymorphonuclear neutrophils

Saad

Benbarek

Franck

et al. 2015

Frontiers in Life Science

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Three Algerian honey samples (nectar honey, mixed honey and honeydew honey) were analysed for their total phenolic content (TPC) using the Folin-Ciocalteu reagent and total flavonoid content (TFC) by the aluminium chloride method. The antioxidant activity was tested both against reactive oxygen species (ROS) produced by phorbol 12-myristate 13-acetate (PMA)-stimulated equine polymorphonuclear neutrophils (PMNs) and on purified equine myeloperoxidase (MPO) enzyme activity. The ROS production by stimulated PMNs was measured by lucigenin-enhanced chemiluminescence. Specific immunological extraction followed by enzymatic detection (SIEFED) was used to measure specifically the activity of equine MPO. Nectar honey, mixed honey and honeydew honey had TPCs of 59.52 ± 1.31, 68.36 ± 1.20 and 122.76 ± 4.20 mg gallic acid equivalents (GAE)/100 g honey, respectively (mean ± SD). As for the TPC, the highest TFC was observed for honeydew honey [20.55 ± 0.72 mg catechine equivalents (CE)/100 mg honey], followed by mixed honey (7.47 ± 0.07 CE/100 mg honey) and nectar honey (4.80 ± 0.08 CE/100 mg honey). All the tested honeys displayed a dosedependent inhibitory effect on the oxidant activities of PMNs. By the SIEFED technique, it was shown that most of the honeys interact directly with MPO: the light honeys (nectar honey and mixed honey) were inhibitors of MPO activity, while the dark honey had less inhibiting effect and even behaved as an enhancer of MPO activity at high concentrations.

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“…Buckwheat hull extract was shown to be effective for protecting biological systems against various oxidative stresses in vitro, and to have antioxidant activity in vivo [71].Buckwheat honey samples were tested for inhibition of reactive oxygen species (ROS) production by activated human PMNs, antioxidant activity (scavenging of superoxide anion in a cell-free system) and inhibition of human complement (reducing levels of ROS by limiting formation of complement factors that attract and stimulate PMNs). Most honey samples were shown to be active inhibitors of reactive oxygen species [72]. The culture and buckwheat dough matrix was evaluated with respect to total phenolic content and antioxidant potential.…”

Section: Iii-pharmacological Effectsmentioning

confidence: 99%

A review on Fagopyrum esculentum: A potential medicinal plant

Al-Snafi¹

2017

IOSRPHR

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Fagopyrum esculentum contained alkaloids, amino acids, anthraquinones, carbohydrates, flavonoids, phlobatannins and tannins. The nutritional analysis of Fagopyrum esculentum flour and bran revealed that they contained starch: 55, 75 and 18%; proteins: 12, 6 and 36%; lipids: 4, 1 and 11%; soluble carbohydrates: 2, 1 and 6%; total dietary fibers: 7, 3 and 15%; and ash: 2, 1 and 7% respectively. The pharmacological studies showed that Fagopyrum esculentum possessed antioxidant, antiinflammatory, cardiovascular, hypolipidemic, antigenotoxic, antidiabetic, reno-protective, anticancer, antimicrobial, wound healing, antistress, protected memory impairment and photoprotective effects. This review will highligh the chemical constituents and pharmacological effects of Fagopyrum esculentum.

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An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey

Cited by 139 publications

References 28 publications

Antimicrobial and anti-inflammatory activities of Apis mellifera honey on the Helicobacter pylori infection of Wistar rats gastric mucosa

Antimicrobial and anti-inflammatory activities of Apis mellifera honey on the Helicobacter pylori infection of Wistar rats gastric mucosa

Effect of honey on purified equine myeloperoxidase activity and superoxide radical production in activated Polymorphonuclear neutrophils

A review on Fagopyrum esculentum: A potential medicinal plant

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