An Idiopathic Febrile Necrotizing Arteritis Syndrome in the Dog: Beagle Pain Syndrome,

Abstract

The clinical, laboratory, and pathologic features ofa syndrome in dogs characterized by intermittent pain, fever, neutrophilia, and necrotizing arteritis are described to alert others involved in toxicity testing to the existence of this disorder. It is considered that this idiopathic syndrome is a latent condition, the expression of which can be precipitated in predisposed dogs by experimental treatment, and thus, its occurrence could complicate interpretation of toxicity studies. We have observed the disorder in 14 beagle dogs. The syndrome is rare and most cases for study were supplied by the breeder. Typical clinical signs observed included evidence of pain when the mouth was opened, grunting when lifted, and standing with an arched back and lowered head. Appetite was usually reduced. Body temperature was elevated (e.g., 104-106°F). There was progressive, bilateral atrophy of temporal and cervical musculature. Such signs have been observed to persist unremittingly or, more commonly, with periods of expression and remission. Neutrophilic leukocytosis and thrombocytosis were present. Hemoglobin and hematocrit were usually slightly decreased. Serum total protein was usually normal but albumin was reduced and alpha-2 globulins were markedly increased. Rheumatoid factor was elevated in several dogs. Arteritis was observed histologically and was characterized by necrosis, intimal proliferation, neutrophil and mononuclear cell infiltration in the media and periarterial tissues, and hemorrhage. Amyloidosis was observed in several dogs. The cause of this disorder is unknown. Knowledge of the distinct features of this syndrome should obviate complication of interpretation of results in toxicity studies and hopefully will lead to studies ofthis syndrome to provide an understanding ofits etiopathogenesis.

Preclinical safety profile of sildenafil

“…14,15 In the literature, an immune-complex mechanism and genetic prePreclinical safety profile of sildenafil D Abbott et al disposition are discussed as possible pathogenesis. [16][17][18] Known to occur spontaneously, BPS appears with greater frequency and severity in treated dogs of toxicological studies.…”

Differentiating Spontaneous from Drug-Induced Vascular Injury in the Dog

“…Many investigators throughout the world have described this syndrome as Beagle pain syndrome (19), juvenile polyarteritis syndrome (44), necrotizing vasculitis (7,43,46), polyarteritis (1,16,27), arteritis (18,37), periarteritis (45), panarteritis (28,40), and idiopathic febrile necrotizing arteritis (19). The specific clinical and morphological presentation of this syndrome will vary, depending upon the stage of disease.…”

“…Clinically, the disease is characterized by recurrent episodes of fever, body weight loss, and cervical pain manifested by a stiff gait and neck with hunched body position. In some dogs, these clinical signs are not detected, even though acute, subacute, or chronic microscopic arterial lesions are observed in multiple organs (7,16,19,28,44). In the acute febrile phase, typical changes in clinical pathology data include leukocytosis with neutrophilia, elevated acute phase proteins (α-2-globulin and fibrinogen), hypoalbuminemia, elevated platelet counts, and mild regenerative anemia (43).…”

Endothelin Antagonist-Induced Coronary and Systemic Arteritis in the Beagle Dog

“…Animals of the same sex and dose group were housed together in controlled environment rooms (15)(16)(17)(18)(19)(20)(21)(22)(23)(24) • C temperature and 40-70% relative humidity) and given 12 hours light/dark illumination. All animals were offered 400 g/day of irradiated SDS Dog Diet A [E] SQC (Special Diet Services, Witham, Essex, UK) and drinking quality tap water ad libitum.…”