An imbalance in the production of proinflammatory and anti-inflammatory cytokines is observed in whole blood cultures of preeclamptic women in comparison with healthy pregnant women

Campos-Cañas, Jorge; Romo-Palafox, Inés; Albani-Campanario, Mario; Hernández‐Guerrero, César

doi:10.3109/10641955.2013.858744

Cited by 20 publications

(10 citation statements)

References 28 publications

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“…IL‐1β level was similar in mild preeclampsia and healthy pregnancies, which is in line with our findings. The role of IL‐6 in placental invasiveness during implantation has been described previously, but results regarding IL‐6 levels in preeclampsia patients are rather controversial . Recent studies have not observed differences in IL‐6 levels between preeclampsia and uncomplicated pregnancies, which is in agreement with our results.…”

Section: Discussionsupporting

confidence: 92%

Glutathione‐S‐transferase M1 polymorphism and pro‐inflammatory cytokines tumour necrosis factor‐α and interleukin‐1β are associated with preeclampsia in Serbian women

Jakovljević

Kontić-Vučinić

Nikolic

et al. 2019

American J Rep Immunol

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Problem Preeclampsia has a multifactorial origin with genetic, immunological, and environmental factors described as main contributors to its onset. This study aimed to investigate glutathione‐S‐transferase M1 (GSTM1) and glutathione‐S‐transferase T1 (GSTT1) gene polymorphisms, the expression of pro‐inflammatory cytokines (TNF‐α, IL‐1β, IL‐6), and the potential relationship between GST polymorphisms and cytokine expression levels in preeclampsia and uncomplicated pregnancy. Method of Study This prospective case‐control study included 50 women with preeclampsia and 50 healthy pregnant women. DNA and RNA were extracted from women leukocytes. Deletion polymorphisms were analyzed by PCR, while cytokine mRNA expression was analyzed by real‐time PCR. Results GSTM1 null genotype with present GSTT1 increased the risk for preeclampsia development. Deletion of GSTT1 without deletion of GSTM1 increased the risk for early preeclampsia. Relative mRNA expression of TNF‐α was significantly higher in preeclampsia compared to healthy pregnant women (P = 0.006). Expression of IL‐1β was significantly higher in severe and late preeclampsia compared to the control group (P = 0.005, P = 0.007, respectively). A significant positive correlation between TNF‐α and IL‐1β was observed (Spearman's ρ = 0.312, P = 0.028) and between IL‐1β and IL‐6, in preeclampsia group (Spearman's ρ = 0.296, P = 0.037). IL‐1β was significantly increased in patients with GSTT1 null genotype (P = 0.015) while IL‐6 was increased in patients with GSTM1 null genotype (P = 0.015). Conclusions GSTM1 null genotype represents a risk factor for preeclampsia development, while GSTT1 null genotype favors early preeclampsia. Preeclampsia is also associated with increased expression of pro‐inflammatory cytokines, predominantly TNF‐α and IL‐1β.

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Section: Discussionsupporting

confidence: 92%

Glutathione‐S‐transferase M1 polymorphism and pro‐inflammatory cytokines tumour necrosis factor‐α and interleukin‐1β are associated with preeclampsia in Serbian women

Jakovljević

Kontić-Vučinić

Nikolic

et al. 2019

American J Rep Immunol

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“…27,[107][108][109] Moreover, a high level of proinflammatory cytokine (IL-1b and IL-6) profile can be demonstrated in preeclampsia. 27,110 DNA oxidation as measured by the expression of 8-OHdG in preeclamptic placenta is higher than in the healthy placentas. 27 Placental senescence in spontaneous preterm labor/birth.…”

Section: Perturbation Of Mitochondrial Homeostasismentioning

confidence: 92%

Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction?

Sultana

Maiti

Dedman

et al. 2018

American Journal of Obstetrics and Gynecology

113

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The placenta ages as pregnancy advances, yet its continued function is required for a successful pregnancy outcome. Placental aging is a physiological phenomenon; however, there are some placentas that show signs of aging earlier than others. Premature placental senescence and aging are implicated in a number of adverse pregnancy outcomes, including fetal growth restriction, preeclampsia, spontaneous preterm birth, and intrauterine fetal death. Here we discuss cellular senescence, a state of terminal proliferation arrest, and how senescence is regulated. We also explore the role of physiological placental senescence and how aberrant placental senescence alters placental function, contributing to the pathophysiology of fetal growth restriction, preeclampsia, spontaneous preterm labor/birth, and unexplained fetal death.

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“…The association of both inflammatory processes and oxidative stress, and their possible role in cellular pathology was reviewed elsewhere . It was also reported that imbalance between anti‐ and pro‐inflammatory cytokines is a potential cause of PE . Unusual increase of pro‐inflammatory cytokines is also reported to be a trigger of maternal endothelial cell abnormality in PE .…”

Section: Introductionmentioning

confidence: 99%

“…12 It was also reported that imbalance between anti-and pro-inflammatory cytokines is a potential cause of PE. 13 Unusual increase of pro-inflammatory cytokines is also reported to be a trigger of maternal endothelial cell abnormality in PE. 14 Pro-inflammatory cytokine levels, such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, have also been reported to be changed during PE.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

Jing

2016

J of Obstet and Gynaecol

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An imbalance in the production of proinflammatory and anti-inflammatory cytokines is observed in whole blood cultures of preeclamptic women in comparison with healthy pregnant women

Abstract: Preeclamptic women showed an imbalance in the production of pro and anti-inflammatory cytokines in comparison with normotensive women.

Cited by 20 publications

References 28 publications

Glutathione‐S‐transferase M1 polymorphism and pro‐inflammatory cytokines tumour necrosis factor‐α and interleukin‐1β are associated with preeclampsia in Serbian women

Glutathione‐S‐transferase M1 polymorphism and pro‐inflammatory cytokines tumour necrosis factor‐α and interleukin‐1β are associated with preeclampsia in Serbian women

Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction?

Vitamin D restores angiogenic balance and decreases tumor necrosis factor‐α in a rat model of pre‐eclampsia

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