An immersed boundary-lattice Boltzmann model for simulation of malaria-infected red blood cell in micro-channel

Navidbakhsh, Mahdi; Rezazadeh, Marzieh

doi:10.1016/j.scient.2012.08.001

Cited by 26 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A popular kinetic model, namely, the discrete Boltzmann equation in the Bhatnagar–Gross–Krook (BGK) model with a single relaxation time under an external force, may be reproduced as follows [ 9 , 18 , 22 , 27 , 29 ]:

where f α eq is the equilibrium distribution function, f α is the distribution function, τ is the single relaxation parameter, δ t is the time interval, e α is the particle velocity, and ω α is a weight coefficient that is determined by the selected lattice velocity model. In the present study, a 2D lattice with nine velocity components, referred to as D2Q9, was employed.…”

Section: Governing Equations and Numerical Methodsmentioning

confidence: 99%

“…Krüger et al [ 21 ] used a hybrid LB-IB-finite element method to simulate the tumbling and tank-treading-like motion of dense suspended RBCs in an external shear flow. The transient motion and deformation of healthy RBCs and PF-RBCs at different stages were examined in a simple 2D microchannel, with the RBCs moving along the center line of the channel [ 22 , 23 ]. Sui et al [ 24 – 26 ] used a combination of the IBM, a multiblock lattice Boltzmann model, and membrane mechanics to investigate the transient behaviors of elastic capsules and the deformation and aggregation of RBCs in a shear flow.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Numerical Simulations of the Motion and Deformation of Three RBCs during Poiseuille Flow through a Constricted Vessel Using IB-LBM

Wang

Wei

et al. 2018

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

The immersed boundary-lattice Boltzmann method (IB-LBM) was used to examine the motion and deformation of three elastic red blood cells (RBCs) during Poiseuille flow through constricted microchannels. The objective was to determine the effects of the degree of constriction and the Reynolds (Re) number of the flow on the physical characteristics of the RBCs. It was found that, with decreasing constriction ratio, the RBCs experienced greater forced deformation as they squeezed through the constriction area compared to at other parts of the microchannel. It was also observed that a longer time was required for the RBCs to squeeze through a narrower constriction. The RBCs subsequently regained a stable shape and gradually migrated toward the centerline of the flow beyond the constriction area. However, a sick RBC was observed to be incapable of passing through a constricted vessel with a constriction ratio ≤1/3 for Re numbers below 0.40.

show abstract

Section: Governing Equations and Numerical Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Numerical Simulations of the Motion and Deformation of Three RBCs during Poiseuille Flow through a Constricted Vessel Using IB-LBM

Wang

Wei

et al. 2018

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

show abstract

“…In their research mitral valve jet flow considering the interaction of leaflets and fluid has been simulated. Navidbakhsh and Rezazadeh [12] carried out a numerical study on the behavior of malaria-infected RBC. Vahidkhah and Abdollahi [13] simulated the motion of a massless elastic object in a twodimensional viscous channel flow numerically using IBM-LBM.…”

Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Interaction Between Red Blood Cell with Surrounding Fluid in Poiseuille Flow

Esmaily¹

2018

AAMM

View full text Add to dashboard Cite

In this research, motion and deformation of a red blood cell (RBC) in a microchannel with stenosis is investigated by combined Lattice Boltzmann-Immersed Boundary method. The fluid flow occurs due to the pressure difference between the inlet and the outlet of the microchannel. The immersed boundary algorithm guaranteed that there is no relative velocity between the RBC and fluid. Therefore, mass transfer along the immersed border does not occur. It can be seen that the healthy RBC has more deformation and passes the stenosis easier while the sick one passes the stenosis with less deformation and returns to its initial state faster. Increasing the pressure gradient (i.e., increasing Reynolds number) would cause more deformation of the RBC. It is found that a healthy RBC moves faster than a sick one along the microchannel. Blood pressure increases due to the presence of stenosis and low deformable RBCs.It is the reason of many serious diseases including cardiovascular diseases. The results of this paper were compared to the previous valid results and good agreements were observed.

show abstract

“…Both experimental [6,7] and numerical [8,9] researches have been conducted on these applications of micro uidics. A structural form of human liver is composed of sinusoids along which various vital metabolisms occurred.…”

Section: Introductionmentioning

confidence: 99%

A numerical model for predicting hepatocytes ureagenesis and its related inborn enzyme deficiencies: case studies

et al. 2018

View full text Add to dashboard Cite

Abstract. One important functionality of liver cells is ammonia detoxi cation and urea production. In this study, a numerical model of the urea cycle in hepatocytes was developed. Navier Stokes and convection equations were employed to study the process of ammonia elimination and urea production using a micro uidic channel. The concentration of urea and ammonia throughout the channel was obtained. Furthermore, the urea cycle was modelled with respect to its four main enzymes. This resulted in twelve rate equations that were solved to determine the concentration of each metabolite participating in the urea cycle. Application of results implied common disorders such as hyperammonemia types I and II and argininosuccinicaciduria types I and II. Result of this study indicated that there is 80% chance of a reduction in concentration of citrulline, argininosuccinate, arginin, carbamoyl phosphate, phosphate and fumarate in hyperammonemia type II. A 10-fold increase of argininosuccinate concentration was observed in both argininosuccinicaciduria types I and II. The predicted result may be useful in better understanding and controlling of metabolite de ciencies in patient abnormalities.

show abstract

An immersed boundary-lattice Boltzmann model for simulation of malaria-infected red blood cell in micro-channel

Cited by 26 publications

References 29 publications

Numerical Simulations of the Motion and Deformation of Three RBCs during Poiseuille Flow through a Constricted Vessel Using IB-LBM

Numerical Simulations of the Motion and Deformation of Three RBCs during Poiseuille Flow through a Constricted Vessel Using IB-LBM

Numerical Simulation of Interaction Between Red Blood Cell with Surrounding Fluid in Poiseuille Flow

A numerical model for predicting hepatocytes ureagenesis and its related inborn enzyme deficiencies: case studies

Contact Info

Product

Resources

About