An Immune-Modulating Diet in Combination with Chemotherapy Prevents Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice

Nakamura, Kentaro; Sasayama, Akina; Takahashi, Takeshi; Yamaji, Taketo

doi:10.1080/01635581.2015.1053495

Cited by 14 publications

(13 citation statements)

References 39 publications

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“…Although some antioxidants seem effective in reverting cancer-induced muscle wasting by reducing inflammation and oxidative stress (7,17), other studies underline that antioxidants may promote tumor growth and reduce radio/chemotherapy efficacy (7). For instance, recent reports on preclinical models of cancer cachexia have shown that quercetin and an immunomodulatory diet (also enriched with antioxidant compounds such as vitamins A, C, E, and zinc and selenium) positively affect muscle mass in Apc Min/+ and C26-bearing mice, respectively (86,142).…”

Section: Potential Impact Of Antioxidants and Exercise Mimetics In Camentioning

confidence: 99%

The Redox Balance: A Target for Interventions Against Muscle Wasting in Cancer Cachexia?

Penna

Ballarò

Costelli

2020

Antioxidants & Redox Signaling

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Significance: The management of cancer patients is frequently complicated by the occurrence of a complex syndrome known as cachexia. It is mainly characterized by muscle wasting, a condition that associates with enhanced protein breakdown and with negative energy balance. While the mechanisms underlying cachexia have been only partially elucidated, understanding the pathogenesis of muscle wasting in cancer hosts is mandatory to design new targeted therapeutic strategies. Indeed, most of cancer patients will experience cachexia during the course of their disease, and about 25% of cancer-related deaths are due to this syndrome, rather than to the tumor itself. Recent Advances: Compelling evidence suggests that an altered redox homeostasis likely contributes to cancerinduced muscle protein depletion, directly or indirectly activating the intracellular degradative pathways. In addition, oxidative stress impinges on both mitochondrial number and function; the other way round, altered mitochondria lead to enhanced redox imbalance, creating a vicious loop that eventually results in negative energy metabolism. Critical Issues: The present review focuses on the possibility that pharmacological and nonpharmacological strategies able to restore a physiologic redox balance could be useful components of treatment schedules aimed at counteracting cancer-induced muscle wasting. Future Directions: Exercise and the use of exercise mimetic drugs represent the most promising approaches capable of reinforcing the muscle antioxidant defenses of cancer patients. The results from ongoing and new clinical trials are needed to validate the preclinical studies and provide effective therapies for cancer cachexia.

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Section: Potential Impact Of Antioxidants and Exercise Mimetics In Camentioning

confidence: 99%

The Redox Balance: A Target for Interventions Against Muscle Wasting in Cancer Cachexia?

Penna

Ballarò

Costelli

2020

Antioxidants & Redox Signaling

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“…This condition continues to worsen while tumor progression is not suppressed. However, cancer treatments such as chemotherapy and radiotherapy might also have adverse effects on patient nutritional status [ 3 ]. Therefore, treatment should simultaneously maintain nutritional status while shrinking tumors.…”

Section: Introductionmentioning

confidence: 99%

A Ketogenic Formula Prevents Tumor Progression and Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice

Nakamura¹,

Tonouchi²,

Sasayama³

et al. 2018

Nutrients

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Low-carbohydrate, high-fat diets (ketogenic diets) might prevent tumor progression and could be used as supportive therapy; however, few studies have addressed the effect of such diets on colorectal cancer. An infant formula with a ketogenic composition (ketogenic formula; KF) is used to treat patients with refractory epilepsy. We investigated the effect of KF on cancer and cancer cachexia in colon tumor-bearing mice. Mice were randomized into normal (NR), tumor-bearing (TB), and ketogenic formula (KF) groups. Colon 26 cells were inoculated subcutaneously into TB and KF mice. The NR and TB groups received a standard diet, and the KF mice received KF ad libitum. KF mice preserved their body, muscle, and carcass weights. Tumor weight and plasma IL-6 levels were significantly lower in KF mice than in TB mice. In the KF group, energy intake was significantly higher than that in the other two groups. Blood ketone body concentrations in KF mice were significantly elevated, and there was a significant negative correlation between blood ketone body concentration and tumor weight. Therefore, KF may suppress the progression of cancer and the accompanying systemic inflammation without adverse effects on weight gain, or muscle mass, which might help to prevent cancer cachexia.

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“…The immunomodulatory potential of natural products was also explored as adjuvant therapy in cancer patients [31]. Recently, immune-modulating diet in combination with chemotherapy has reported preventing cancer cachexia without suppressing chemotherapeutic efficacy [32]. However, clinical evidence for such immunological benefits for reduction of chemotherapy side effects is lacking.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Standardized Cinnamon Bark Extract for the Prevention of Chemotherapy-Induced Weight Loss and Alopecia in Patients With Breast Cancer: A Randomized, Double-Blind, and Placebo-Controlled Study

Mehta

Thakurdesai

2019

Asian J Pharm Clin Res

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Objective: The objective of the study was to evaluate the effects of IND02 (standardized Cinnamon bark extract) supplementation for the prevention of side effects of cancer chemotherapy in female patients with breast cancer. Methods: The study was conducted using double-blind, placebo-controlled design in 34 female breast cancer patients during the first 4 consecutive 21-day cycles of the standard chemotherapy regimen. The active treatment (IND02 capsules, 400 mg, one capsule, and thrice a day) or matching placebo was orally administrated in randomized (1:1 ratio) patients. The efficacy outcome measures were reduction in chemotherapy-induced weight loss, alopecia (hair fall), and other side effects. The safety outcome measures were hematology, ECG, vital signs, adverse event monitoring, and laboratory safety measurements. Results: The patients on the treatment with IND02 had shown significant protection from chemotherapy-induced severe weight loss (cachexia) and alopecia (reduced hair density and % hairs in the anagen phase, and increased % hairs in telogen phase) which was seen in the placebo group. IND02 treatment was found safe and well-tolerated during the study. Conclusion: Concomitant use of IND02 in breast cancer patients during breast cancer chemotherapy showed a clinical promise regarding efficacy and safety in preventing chemotherapy-induced weight loss and alopecia.

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An Immune-Modulating Diet in Combination with Chemotherapy Prevents Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice

Cited by 14 publications

References 39 publications

The Redox Balance: A Target for Interventions Against Muscle Wasting in Cancer Cachexia?

The Redox Balance: A Target for Interventions Against Muscle Wasting in Cancer Cachexia?

A Ketogenic Formula Prevents Tumor Progression and Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice

Efficacy and Safety of Standardized Cinnamon Bark Extract for the Prevention of Chemotherapy-Induced Weight Loss and Alopecia in Patients With Breast Cancer: A Randomized, Double-Blind, and Placebo-Controlled Study

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