An Immune‐Regulating Polysaccharide Hybrid Hydrogel with Mild Photothermal Effect and Anti‐Inflammatory for Accelerating Infected Wound Healing

Abstract

Bacterial infections and excessive inflammation present substantial challenges for clinical wound healing. Hydrogels with mild photothermal (PTT) effects have emerged as promising agents owing to their dual actions: positive effects on cells and negative effects on bacteria. Here, an injectable self‐healing hydrogel of oxidized konjac glucomannan/arginine‐modified chitosan (OKGM/CS‐Arg, OC) integrated with protocatechualdehyde‐@Fe (PF) nanoparticles capable of effectively absorbing near‐infrared radiation is synthesized successfully. The OC/PF hydrogels exhibit excellent mechanical properties, biocompatibility, and antioxidant activity. Moreover, in synergy with PTT, OC/PF demonstrates potent antibacterial effects while concurrently stimulating cell migration and new blood vessel formation. In methicillin‐resistant Staphylococcus aureus‐infected full‐thickness mouse wounds, the OC/PF hydrogel displays remarkable antibacterial and anti‐inflammatory activities, and accelerates wound healing by regulating the wound immune microenvironment and promoting M2 macrophage polarization. Consequently, the OC/PF hydrogel represents a novel therapeutic approach for treating multidrug‐resistant bacterial infections and offers a technologically advanced solution for managing infectious wounds in clinical settings.

Metal–Polyphenol–Collagen Self-Assembled Bioadhesive with Immune Regulation for Infected Wound Healing

“…Currently, hydrogels have been developed as ideal scaffold materials for tissue engineering and biomedical applications with the characteristics of advantageous tunability, manufacturability, and biocompatibility. The three-dimensional cross-linked network rich in hydrophilic groups of hydrogels can not only act as favorable vehicles for bioactive cytokines or nanoparticles but also construct a suitable physicochemical microenvironment supporting cell growth, which is conducive to the rapid restoration of cutaneous wounds. , Significantly, the exudative and moist wound surfaces require hydrogels to possess the properties of tissue adhesion in the dynamic physiological environment so that they can effectively seal the wounds and provide an optimal humidity value for wound healing. Also, the bioadhesive hydrogel dressings do not need to be replaced and stripped frequently, which can minimize the risks of secondary damage, infection or bleeding .…”