An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

Abstract

Background Laryngeal squamous cell carcinoma (LSCC) is the most common squamous cell carcinoma. Though significant effort has been focused on molecular pathogenesis, development, and recurrence of LSCC, little is known about its relationship with the immune-related long non-coding RNA (lncRNA) pairs. Methods After obtaining the transcriptome profiling data sets and the corresponding clinical characteristics of LSCC patients and normal samples from The Cancer Genome Atlas (TCGA) database, a series of bioinformatic analysis was conducted to select the differently expressed immune-related lncRNAs and build a signature of immune-related lncRNA pairs. Then, the effectiveness of the signature was validated. Results A total of 111 LSCC patients and 12 normal samples’ transcriptome profiling data sets were retrieved from TCGA. 301 differently expressed immune-related lncRNAs were identified and 35,225 lncRNA pairs were established. After univariate Cox analysis, LASSO regression and multivariate Cox analysis, 7 lncRNA pairs were eventually selected to construct a signature. The riskscore was computed using the following formula: Riskscore = 0.95 × (AL133330.1|AC132872.3) + (-1.23) × (LINC01094|LINC02154) + 0.65 × (LINC02575|AC122685.1) + (-1.15) × (MIR9-3HG|LINC01748) + 1.45 × (AC092687.3|SNHG12) + (-0.87) × (AC090204.1|AL158166.1) + 0.64 × (LINC01063|Z82243.1). Patients were classified into the high-risk group (> 1.366) and the low-risk group (< 1.366) according to the cutoff value (1.366), which is based on the 5-year riskscore ROC curve. The survival analysis showed that the low-risk group had a better prognosis (P < 0.001). The riskscore was better than other clinical characteristics in prognostic prediction and the area under the curves (AUCs) for the 1-, 3-, and 5-year survivals were 0.796, 0.946, and 0.895, respectively. Combining age, gender, grade, stage, and riskscore, a nomograph was developed to predict survival probability in LSCC patients. Then, the riskscore was confirmed to be related with the content of tumor-infiltration immune cells and the model could serve as a potential predictor for chemosensitivity. Conclusion We successfully established a more stable signature of 7 immune-related lncRNA pairs, which has demonstrated a better prognostic ability for LSCC patients and may assist clinicians to precisely prescribe chemo drugs.

Construction of a redox-related gene signature for overall survival prediction and immune infiltration in non-small-cell lung cancer

“…The previous prognostic signatures in other cancers showed better diagnostic performance, with an AUC value of more Frontiers in Molecular Biosciences frontiersin.org than 0.8 (Qian et al, 2022;Zhang et al, 2022). However, in the current study, the AUC value for OS at the 5 year periods was 0.657 in TCGA and 0.717 in GSE31210.…”

“…In the present study, the redox-related gene signature was first constructed in all the patients with NSCLC, and Kaplan–Meier survival curve showed that the high-risk group had a worse OS than the low-risk group, which was different from and cannot be replaced by the previously constructed signature using hypoxia-related gene ( Chen et al, 2022 ), pyroptosis-related gene ( Zhang and Yan, 2021 ; Li et al, 2022 ), autophagy-related gene ( Wu et al, 2021a ), and inflammatory response-related gene ( Zou et al, 2021 ) because it could be meaningful in exploring the value of the redox-related gene in initiation, progression, prognosis, and therapy of NSCLC. The previous prognostic signatures in other cancers showed better diagnostic performance, with an AUC value of more than 0.8 ( Qian et al, 2022 ; Zhang et al, 2022 ). However, in the current study, the AUC value for OS at the 5 year periods was 0.657 in TCGA and 0.717 in GSE31210.…”

Clinical significance and immune landscape of cuproptosis-related lncRNAs in kidney renal clear cell carcinoma: a bioinformatical analysis

“…AC002451 is one of the ferroptosisrelated lncRNAs related to poor prognosis of gastric adenocarcinoma (26). Some studies have shown that linc02154 may serve as a valuable biomarker to predict the prognosis and indicate the immune status in laryngeal squamous cell carcinoma and as a potential therapeutic target (27)(28)(29). Another study indicated that LINC02154 facilitates hepatocellular carcinoma proliferation and metastasis by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway (30).…”

Qualification of Necroptosis-Related lncRNA to Forecast the Treatment Outcome, Immune Response, and Therapeutic Effect of Kidney Renal Clear Cell Carcinoma

“…An axis linking an lncRNA with a microRNA and the target gene was shown in bladder cancer progression and metastasis [ 48 , 49 ]. A similar approach has been used to study laryngeal squamous cell carcinoma [ 50 ].…”