An immunisation strategy for the protection of cattle against alcelaphine herpesvirus-1-induced malignant catarrhal fever

Haig, David M.; Grant, Dawn M.; Deane, David; Campbell, Iain; Thomson, Jackie; Jepson, Catherine D.; Buxton, D.; Russell, George C.

doi:10.1016/j.vaccine.2008.06.056

Cited by 47 publications

(66 citation statements)

References 27 publications

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“…Vaccination attempts have been performed with variable success (48)(49)(50). However, all strategies reside on the use of attenuated or inactivated WT virus, and full protection was unfortunately never obtained.…”

Section: Discussionmentioning

confidence: 99%

An essential role for γ-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle

Palmeira

Sorel

Campe

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Wildebeests carry asymptomatically alcelaphine herpesvirus 1 (AlHV-1), a γ-herpesvirus inducing malignant catarrhal fever (MCF) to several ruminant species (including cattle). This acute and lethal lymphoproliferative disease occurs after a prolonged asymptomatic incubation period after transmission. Our recent findings with the rabbit model indicated that AlHV-1 infection is not productive during MCF. Here, we investigated whether latency establishment could explain this apparent absence of productive infection and sought to determine its role in MCF pathogenesis. First, whole-genome cellular and viral gene expression analyses were performed in lymph nodes of MCF-developing calves. Whereas a severe disruption in cellular genes was observed, only 10% of the entire AlHV-1 genome was expressed, contrasting with the 45% observed during productive infection in vitro. In vivo, the expressed viral genes included the latency-associated nuclear antigen homolog ORF73 but none of the regions known to be essential for productive infection. Next, genomic conformation analyses revealed that AlHV-1 was essentially episomal, further suggesting that MCF might be the consequence of a latent infection rather than abortive lytic infection. This hypothesis was further supported by the high frequencies of infected CD8 + T cells during MCF using immunodetection of ORF73 protein and single-cell RT-PCR approaches. Finally, the role of latency-associated ORF73 was addressed. A lack of ORF73 did not impair initial virus replication in vivo, but it rendered AlHV-1 unable to induce MCF and persist in vivo and conferred protection against a lethal challenge with a WT virus. Together, these findings suggest that a latent infection is essential for MCF induction.

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Section: Discussionmentioning

confidence: 99%

An essential role for γ-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle

Palmeira

Sorel

Campe

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…These similarities may relate to the invasiveness of M. bovis which causes extensive lung lesions which was also typically seen in MCF infections (Reynolds et al, 1985;Howard et al, 1986;Haig et al, 2008 andRussell et al, 2009). Invasive AlHV-1 given at a fatal dose as demonstrated in the immunization study in this chapter might evoke IgG responses since IgG plasma cells predominate in the lower respiratory tract (compared with IgA cells in the upper tract, Morgan et al, 1981).…”

Section: Dige Analysismentioning

confidence: 93%

“…Recently, an immunisation strategy developed by Haig et al (2008) using prime vaccination and boost immunisations of attenuated AlHV-1 in adjuvant intramuscularly in the upper neck to stimulate a mucosal barrier of virus-neutralising antibody in the nasal and oropharyngeal region. This approach has successfully protected cattle challenged intranasally with a fatal dose of virulent AlHV-1.…”

Section: Malignant Catarrhal Fevermentioning

confidence: 99%

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Biochemical and proteomic investigation of bovine nasal secretion

Ghazali

Jonsson

Burchmore

et al. 2012

Farm Animal Proteomics

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“…By contrast, most newborn wildebeest calves are infected and shed virus continuously until 3-4 months of age, and are the primary virus source for transmission (Mushi et al, 1981). Cell tropisms are different between the two viruses: AlHV-1 readily grows in various cell lines (Plowright, 1990) and infection can be induced in cattle or rabbits by cell-free virus through various routes, including intranasally, intramuscularly and intravenously (Haig et al, 2008;Mushi, 1980). In contrast, OvHV-2 has not been propagated in vitro yet, even in cell lines that can support AlHV-1 in vitro propagation.…”

Section: Introductionmentioning

confidence: 99%

Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits

Cunha

Gailbreath

et al. 2011

Veterinary Microbiology

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An immunisation strategy for the protection of cattle against alcelaphine herpesvirus-1-induced malignant catarrhal fever

Cited by 47 publications

References 27 publications

An essential role for γ-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle

An essential role for γ-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle

Biochemical and proteomic investigation of bovine nasal secretion

Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits

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