An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis

Ya-You, Ji; Liu, Yanfang; Boyun, Wang; Yang, Daizhi

doi:10.1002/1097-0142(19890915)64:6<1281::aid-cncr2820640619>3.0.co;2-7

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…This finding has been most likely associated with erythrophagocytosis, diminish production because of cellular infiltration of the bone marrow, immune‐mediated disease, or a combination 1,15 . Hyperferritinemia has also been associated with MH in a dog 16 and humans 17,18 . However, hyperferritinemia has been found in other tumors in human beings 17 …”

Section: Introductionmentioning

confidence: 99%

Sonographic Features of Histiocytic Neoplasms in the Canine Abdomen

Cruz-Arambulo

Wrigley

Powers

2004

Vet Radiology Ultrasound

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The purpose of this retrospective study was to describe the ultrasonographic features of malignant histiocytosis (MH), malignant fibrous histiocytoma, and histiocytic sarcoma in abdominal organs of dogs. The medical records of 18 dogs that had undergone abdominal sonography and had a histopathologic diagnosis of abdominal MH, malignant fibrous histiocytoma, and histiocytic sarcoma were reviewed. The organ most commonly affected was the spleen. MH was the most common followed by histiocytic sarcoma and malignant fibrous histiocytoma. In the spleen there were often multiple hypoechoic nodules with well-defined borders. In one dog, without focal lesions, the spleen was enlarged and hypoechoic. The liver was the second most commonly affected organ. MH was most common followed by histiocytic sarcomas and malignant fibrous histiocytoma. The most common sonographic feature in the liver was the presence of multiple hypoechoic nodules with well-defined borders. One dog without hepatic nodules had a liver that was ultrasonographically enlarged and hypoechoic. MH in the abdominal lymph nodes resulted in hypoechoic lymphadenopathy. Malignant fibrous histiocytoma was the only neoplastic type in the kidneys appearing as a single heteroechoic renal mass with well-defined borders. MH was observed in the stomach of one dog. Sonographically there was a single well circumscribed hypoechoic mass with well-defined borders and abnormal stomach layers. In this study it was not possible to differentiate between MH, malignant fibrous histiocytoma, and histiocytic sarcoma using sonography.

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Section: Introductionmentioning

confidence: 99%

Sonographic Features of Histiocytic Neoplasms in the Canine Abdomen

Cruz-Arambulo

Wrigley

Powers

2004

Vet Radiology Ultrasound

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“…6 In people, hyperferritinemia, unrelated to iron stores, is recognized in several malignancies, including tumors of histiocytic origin. [6][7][8][9][10][11] Hyperferritinemia has been documented in several malignancies of dogs, particularly HS and lymphoma. a,12, 13 In addition, hyperferritinemia occurs in people with hemolytic disorders and liver disease.…”

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confidence: 99%

“…Ferritin is an iron storage and acute phase protein made by hepatocytes and cells of hematopoietic origin 6 . In people, hyperferritinemia, unrelated to iron stores, is recognized in several malignancies, including tumors of histiocytic origin 6–11 . Hyperferritinemia has been documented in several malignancies of dogs, particularly HS and lymphoma a 12,13 .…”

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confidence: 99%

Evaluation of Serum Ferritin as a Tumor Marker for Canine Histiocytic Sarcoma

Friedrichs

Thomas

Plier³

et al. 2010

Journal of Veterinary Internal Medicine

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Background: Canine histiocytic sarcoma (HS) is an aggressive malignancy. Hyperferritinemia has been documented in dogs with HS and could serve as a tumor marker aiding in diagnosis and treatment. In people, hyperferritinemia is found in inflammatory diseases, liver disease, and hemolysis, and thus may occur in dogs with these conditions.Objective: To determine if serum ferritin concentration is a tumor marker for canine HS. Animals: Dogs with HS (18), inflammatory diseases (20), liver disease (24), immune-mediated hemolytic anemia (IMHA) (15), and lymphoma (23).Methods: Prospective, observational, cohort study: Serum ferritin concentration was measured at initial diagnosis. Parametric methods were used to compare mean log ferritin concentrations among disease categories. Receiver-operating characteristic curves and likelihood ratios were used to evaluate serum ferritin concentration as a tumor marker.Results: Varying proportions of dogs with IMHA (94%), HS (89%), liver disease (79%), lymphoma (65%), and inflammatory diseases (40%) had hyperferritinemia. Dogs with IMHA had significantly higher mean ferritin concentration than dogs in all other categories. Dogs with HS had significantly higher mean ferritin concentration than those in the inflammatory disease and lymphoma categories. Mean serum ferritin concentration was not significantly different between dogs with HS and those with liver disease. Decision thresholds were determined to distinguish IMHA and HS from the other diseases associated with hyperferritinemia.Conclusion: Hyperferritinemia is common in dogs with HS and, after IMHA is ruled out, the degree of hyperferritinemia may be useful in differentiating dogs with HS from dogs with inflammatory diseases, liver disease, and lymphoma.

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Transformation of chronic lymphocytic leukemia to lymphoma of true histiocytic type

Wetzler

Kurzrock

Goodacre

et al. 1995

Cancer

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Background. Chronic lymphocytic leukemia (CLL) may evolve into large cell lymphoma (Richter's syndrome), prolymphocytic leukemia, acute lymphoblastic leukemia, and myeloma. Methods. A patient with CLL that transformed into a lymphoma of true histiocytic type is described, and the literature on the association of these two disorders is reviewed. Results. Lymphomas of true histiocytic type developing as an aggressive terminal phase of CLL previously have been reported in nine patients. Fever and rapidly increasing lymphadenopathy and splenomegaly were the most common signs and symptoms. As with de novo lymphoma of true histiocytic type, extranodal involvement of the soft tissue, gastrointestinal tract, kidneys, bone marrow, liver, and lungs was documented among the 10 patients with lymphoma of true histiocytic type transformed from CLL. The median interval between diagnosis of CLL and the evolution to lymphoma of true histiocytic type was 25.5 months. Patients with lymphomas of true histiocytic type after CLL were treated with fludarabine and various other combination chemotherapy regimens with only short‐lived responses. The median time to death after transformation was only 33 days (range, 10 days to 5 months). Conclusion. Lymphomas of true histiocytic type appear to represent an additional, though uncommon, form of transformation in CLL. Although their presentation is reminiscent of other intermediate to high grade lymphomas, they can be distinguished based on their morphologic and immunophenotypic features. In the patients described in this study to date, transformation of CLL to lymphomas of true histiocytic type is a poor prognostic sign, with survival generally of only days to weeks. Cancer 1995; 76:609–17.

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An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis

Cited by 8 publications

References 26 publications

Sonographic Features of Histiocytic Neoplasms in the Canine Abdomen

Sonographic Features of Histiocytic Neoplasms in the Canine Abdomen

Evaluation of Serum Ferritin as a Tumor Marker for Canine Histiocytic Sarcoma

Transformation of chronic lymphocytic leukemia to lymphoma of true histiocytic type

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