An immunofluorescence study of primary anetoderma

Bergman, Reuven; Friedman‐Birnbaum, Rachel; Hazaz, Bilha; Cohen, E. Lipman; Munichor, Mariana; Lichtig, Chaim

doi:10.1111/j.1365-2230.1990.tb02048.x

Cited by 34 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early lesions may show signs of vasculitis [1]; we found vascu litis in 3 of our patients. In some of the patients with symp toms suggestive of SLE we found that immunofluorescence examinations of the skin, in agreement with previous stud ies of PA patients, seemed to be of minor importance in establishing the diagnosis of definite SLE [19].…”

Section: Discussionsupporting

confidence: 77%

Antiphospholipid Antibodies and Anetoderma: Are They Associated?

Stephansson

Niemi

1995

Dermatology

View full text Add to dashboard Cite

Background: Macular atrophy or anetoderma is a rare skin disease of unknown pathogenesis, characterised by wrinkled or flaccid skin. Objective: The finding of anetoderma in 5 patients followed up because of false-positive seroreactions of syphilis prompted us to study the occurrence of antiphospholipid (aPL) antibodies in anetoderma. Methods: 14 unselected patients with primary anetoderma (PA) were collected from hospital records and clinical, immunological and histological findings were compared in the two patient groups. Results: Of the 5 patients, 3 fulfilled the criteria for antiphospholipid syndrome. In two cases, it was secondary to systemic lupus erythematosus (SLE). Of the 14 PA patients 1 had aPL antibodies and 4 had borrelia antibodies. Two patients had thyroid antibodies; 1 of them developed SLE. In several biopsy specimens, microthromboses were seen in both patient groups. Conclusion: On the basis of this study and our previous findings, it seems that anetoderma is more often associated with aPL-positive SLE or lupus-like disease than with aPL-negative disease. Immunological mechanisms play an important role in both primary and secondary anetoderma. The meaning of false-positive serological tests for syphilis or borrelia and aPL antibodies is not clear, but they may be reacting to some still unidentified antigen. Probably, various systemic as well as local inflammatory and non-inflammatory processes, e.g. microthromboses, can trigger anetoderma via still unknown pathomechanisms.

show abstract

Section: Discussionsupporting

confidence: 77%

Antiphospholipid Antibodies and Anetoderma: Are They Associated?

Stephansson

Niemi

1995

Dermatology

View full text Add to dashboard Cite

show abstract

“…Both groups demonstrated deposits of IgM and C3 in a granular pattern along the dermoepidermal junction, a fibrillar and granular pattern between collagen fibers in the dermis, and C3 on residual elastic fibers. Subsequently, other investigators reported similar findings in isolated cases [14,[20][21][22][23] (overalleight cases until 1990). Most of these patients, in addition, showed various serologic abnormalities, including ANA, anti-n-DNA, LE cells, hypocomplementemia, biologic false positive test for syphilis, rheumatoid factor, and elevated levels of serum immunoglobulins.…”

Section: Introductionsupporting

confidence: 66%

Primary Anetoderma and Antiphospholipid Antibodies—Review of the Literature

Hodak

David

2007

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Primary anetoderma (PA) is a rare elastolytic disorder that develops in clinically normal skin or following a nonspecific inflammatory process. The old literature contains numerous reports of the association between PA and lupus eryhtematosus, although the relationship has not been clearly established. In recent years, there has been a growing body of literature linking PA with a wide range of immunologic abnormalities, the most common of which is the presence of antiphospholipid antibodies, with or without antiphospholipid syndrome. The present review summarizes the literature, from the early descriptions pointing toward an immunologic basis of PA and up to the present recognition that PA is a cutaneous sign for autoimmune disorders, in general, and the presence of antiphospholipid in particular.

show abstract

“…23 Associated conditions. Secondary anetoderma has been associated with urticaria pigmentosa, 24 syphilis, 25 acne, 26 varicella, 27 Lyme disease, 28 leprosy, 29 HIV infection, 30,31 lymphoproliferative disorders, 32,33 Langerhans cell histiocytosis, 34 systemic lupus erythematosus, 14,35,36 primary hypothyroidism, 37 Graves disease, 38 Addison disease, 14 antiphospholipid syndrome, 39 Sjögren syndrome, 40 prurigo nodularis, 41 pilomatricoma, 42,43 application of leeches, 44 electrocardiographic lead placement, 45 hepatitis B vaccination, 46 chronic angular cheilitis, 47 congenital melanocytic nevi with hamartomatous features, 48 juvenile xanthogranuloma, 49 and generalized granuloma annulare. 50 Involvement of extracutaneous elastic tissue has not been reported.…”

Section: Anetodermamentioning

confidence: 99%