An immunohistochemical study of endocrine differentiation of gastric adenocarcinoma

Ooi, AT; M, Mai; Ueda, Hitoshi; Ogino, Tomomi; Takahashi, Yuta; Nakanishi, I; Kawahara, Ei

doi:10.1016/0022-4731(87)91199-x

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“…However, there have been few reports about the research of endocrinal regulation of gastroenteric nonendocrinal tumor and its mechanism with in situ hybridization. Chen [3] and Ooi [4] found endocrine granules or hormones in the common gastroenteric carcinoma cells and in the tumor endocrine cells of the digestive tract with ultrastructural and immunohistochemical techniques. However, immunohistochemical techniques could only show the gastroenteric hormone preserved in a certain kind of tumor cells, but could neither reveal whether the hormone came from protein synthesis by itself or was the exogenous substance, non distinguish if amino acid composition was similar, such as α or β cGRP [5] by proteins or polypeptides.…”

Section: Discussionmentioning

confidence: 99%

Expression of somatostatin mRNA in various differentiated types of gastric carcinoma

Zhang¹

1998

WJG

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AIM To investigate the expression of somatostatin mRNA in various differentiated types of gastric carcinoma. METHODS By using in situ hybridization and immunohistochemical techniques, the expression of somatostatin mRNA and somatostatin immunoreactivity in the normal gastric mucosa, the poorly, moderately and well-differentiated gastric carcinomas, and various clinical stages of carcinoma were observed. RESULTS In comparison with the normal gastric mucosa, the significantly increased expression of somatostatin mRNA positive cells was displayed in gastric carcinoma ( t = 2.681, P < 0.01). The positive signal cells were distributed in a scattered form or aggregated as a mass or a cord, and the positive cells were more significantly enhanced in poorly differentiated carcinomas than those in well and moderately differentiated carcinomas (t = 2.962, P< 0.01). The somatostatin mRNA hybridization signals in stages III and IV of gastric carcinoma were significantly higher than those in stages I and II. The results of somatostatin immunoreactivity were consistent with those of in situhybridization. CONCLUSION The alteration of the expression of somatostatin mRNA was associated with the development of gastric carcinoma and may play an important role in the process of tumor differentiation.

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Section: Discussionmentioning

confidence: 99%

Expression of somatostatin mRNA in various differentiated types of gastric carcinoma

Zhang¹

1998

WJG

View full text Add to dashboard Cite

show abstract

An immunohistochemical study of endocrine differentiation of gastric adenocarcinoma

Cited by 1 publication

References 0 publications

Expression of somatostatin mRNA in various differentiated types of gastric carcinoma

Expression of somatostatin mRNA in various differentiated types of gastric carcinoma

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