1995
DOI: 10.1007/bf00262708
|View full text |Cite
|
Sign up to set email alerts
|

An immunohistochemical study of immunological phenomena in minor salivary glands in patients with Sjögren's syndrome

Abstract: Using different monoclonal antibodies, we performed an immunofluorescent technique on labial salivary glands in order to investigate the immunological phenomena involved in Sjögren's syndrome (SS). An aberrant expression of HLA-DR molecules was detected on cytoplasm of epithelial labial salivary cells in 9 out of 19 (47%) patients, with SS. No such expression was found in 8 patients without SS or in 3 normal controls. HLA-DQ molecules were demonstrated also in two out of ten SS patients without HLA-DR. A lymph… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
5
0

Year Published

2001
2001
2021
2021

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(5 citation statements)
references
References 27 publications
0
5
0
Order By: Relevance
“…The role of ICAM.1 in the pathogenesis of Sjogren's syndrome has been previously investigated [11–18]. Although in all previous reports, the mononuclear infiltrates appeared the principal cellular source of ICAM.1 in tissues from SS patients, ductal or acinar glandular epithelial expression has been reported in some of the studies [15–18].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The role of ICAM.1 in the pathogenesis of Sjogren's syndrome has been previously investigated [11–18]. Although in all previous reports, the mononuclear infiltrates appeared the principal cellular source of ICAM.1 in tissues from SS patients, ductal or acinar glandular epithelial expression has been reported in some of the studies [15–18].…”
Section: Discussionmentioning
confidence: 99%
“…Finally, epithelial type‐specific regulatory mechanisms might also participate, as implied by the differential ICAM.1 expression observed between acinar epithelial, ductal epithelial and myoepithelial cells. In this context, it may be relevant that the epithelial‐specific protein secretory component, which is reportedly over‐expressed by the salivary acinar cells of SS patients [13], may act as an intrinsic inhibitor of ICAM.1 expression [30].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The potential role of conventional CD4 + T helper cells in the pathogenesis of SS have been reported in the recent literature . These cells are proposed to play an important role in the induction and maintenance of the disease . However, little is known regarding the involvement of mucosal‐associated invariant T (MAIT) cells in the pathogenesis of pSS.…”
Section: Introductionmentioning
confidence: 99%
“…Modulation of immune response by SGECs is of particular interest as demonstrated by the aberrantly expressed class II MHC molecules [7][8][9][10][11][12][13][14][15] and co-stimulatory molecules [15][16][17][18][19] . SGECs also induce proliferation of anti-CD3-stimulated CD4 T cells in vitro 17,20 .…”
Section: Introductionmentioning
confidence: 99%