An Immunohistochemical Study of β-catenin Expression and Immune Cell Population in Metastatic Carcinoma to the Liver

Au, Kin Pan; Lo, Regina Cheuk‐Lam

doi:10.3389/pore.2021.1609752

Cited by 3 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Tumor microenvironment immune cells constitute a key component of tumor tissue [ 23 ]. Tumor infiltrating immune cells are an integral component of the tumor microenvironment, and their composition and distribution are thought to be associated with cancer prognosis.…”

Section: Discussionmentioning

confidence: 99%

A Potential Prognostic Biomarker for Glioma: Aldo-Keto Reductase Family 1 Member B1

Zhao

Dong

Huang

et al. 2022

Computational Intelligence and Neuroscience

View full text Add to dashboard Cite

Aldo-keto reductase family 1 member B1 (AKR1B1) plays a vital role in tumor development and is involved in the tumor immune process. However, its role in glioma cell is poorly studied. This study’s aim was to assess the role of AKR1B1 in glioma through bioinformatics analysis. The AKR1B1 expression data and corresponding clinical data of glioma were collected from the Cancer Genome Atlas (TCGA) database. The R packages were used for data integration, extraction, analysis, and visualization. According to the median value of the risk score, all patients were divided into high-risk and low-risk groups to draw the Kaplan–Meier (KM) survival curves and to explore the level of immune infiltration. The expression of AKR1B1 was significantly elevated in glioma tissues compared to normal tissues ( P < 0.001). The high expression of AKR1B1 was significantly associated with WHO grade ( P < 0.001), IDH status ( P < 0.001), 1p/19q codeletion ( P < 0.001), primary therapy outcome ( P = 0.004), and age ( P < 0.05). Kaplan–Meier survival analysis found that OS (HR = 3.75, P < 0.001), DSS (HR = 3.85, P < 0.001), and PFI (HR = 2.76, P < 0.001) were lower in patients with glioma with high AKR1B1 expression than in the group with low AKR1B1 expression. Based on GESA, six pathways (including interferon gamma signaling, signaling by interleukins, cell cycle checkpoints, cytokine receptor interaction, cell adhesion molecules (CAMs), and cell surface interactions) at the vascular wall were identified as significantly different between the two groups. Moreover, highly expressed AKR1B1 was associated with immune cell infiltration. AKR1B1 plays a key role in glioma progression and prognosis and, therefore, serves as a potential biomarker for prediction of patients’ survival.

show abstract

Section: Discussionmentioning

confidence: 99%

A Potential Prognostic Biomarker for Glioma: Aldo-Keto Reductase Family 1 Member B1

Zhao

Dong

Huang

et al. 2022

Computational Intelligence and Neuroscience

View full text Add to dashboard Cite

show abstract

“…Co-expression of CD166/β-catenin, CD44/β-catenin, and CD44/CD166/β-catenin were significant factors associated with liver metastasis, suggesting that specific combinations of CSC markers and β-catenin and additional analyzed proteins could be a significant predictor of poor survival in stage II CRC [128]. Finally, a recent study analyzing liver metastasis from different origins found that β-catenin overexpression was frequent in metastasis from CRC patients (27 out of 30 samples), but also breast (3/5), lungs (1/2), and some other sites [129]. Another study analyzed the expression of β-catenin, APC, and Wnt1 in the primary tumor and corresponding metastasis of patients with CRC.…”

Section: Aberrant Expression Of Wnt Signaling Pathway Components Correlates With the Ability Of Crc To Metastasize To The Livermentioning

confidence: 97%

Wnt Signaling Pathway Is among the Drivers of Liver Metastasis

Samaržija

2021

Livers

View full text Add to dashboard Cite

Liver metastasis, originating either from a primary liver or other cancer types, represent a large cancer-related burden. Therefore, studies that add to better understanding of its molecular basis are needed. Herein, the role of the Wnt signaling pathway in liver metastasis is outlined. Its role in hepatocellular carcinoma (HCC) epithelial-mesenchymal transition (EMT), motility, migration, metastasis formation, and other steps of the metastatic cascade are presented. Additionally, the roles of the Wnt signaling pathway in the liver metastasis formation of colorectal, breast, gastric, lung, melanoma, pancreatic, and prostate cancer are explored. The special emphasis is given to the role of the Wnt signaling pathway in the communication between the many of the components of the primary and secondary cancer microenvironment that contribute to the metastatic outgrowth in the liver. The data presented herein are a review of the most recent publications and advances in the field that add to the idea that the Wnt pathway is among the drivers of liver metastasis and that its targeting could potentially relieve liver metastasis–related complications.

show abstract

Hepatic cell junctions: Pulling a double‐duty

Van Campenhout,

Vinken

2024

Liver International

View full text Add to dashboard Cite

Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver‐specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.

show abstract

An Immunohistochemical Study of β-catenin Expression and Immune Cell Population in Metastatic Carcinoma to the Liver

Cited by 3 publications

References 17 publications

A Potential Prognostic Biomarker for Glioma: Aldo-Keto Reductase Family 1 Member B1

A Potential Prognostic Biomarker for Glioma: Aldo-Keto Reductase Family 1 Member B1

Wnt Signaling Pathway Is among the Drivers of Liver Metastasis

Hepatic cell junctions: Pulling a double‐duty

Contact Info

Product

Resources

About