An Immunohistochemical Study on Neurons and Paraneurons of the Pre- and Post-Natal Chicken Lung.

Salvi, Elisa; Renda, T

doi:10.1679/aohc.55.125

Cited by 17 publications

(13 citation statements)

References 32 publications

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“…However, the highest density of serotonin-positive cells was observed on ED 17. Such a transient increase in neuroendocrine cells during the perinatal periods has been widely reported for various peptides [2,4,5,8,9,21,24, 27] including CGRP [3]. In the present study, CGRP, PGP 9.5, serotonin and chromogranin A positive endocrine cells all appeared at the primitive bronchi, extended along the developing bronchial trees and increased in number during the late fetal periods, suggesting that these cells may play a critical role for the cellular differentiation or for the cellular proliferation in bronchial development.…”

Section: Discussionsupporting

confidence: 55%

Change in Distribution and Density of CGRP, PGP 9.5, Serotonin and Chromogranin A Immunoreactivity in the Perinatal Rat Respiratory Tract.

Inoue

Fujimiya

Maeda

et al. 1997

Acta Histochem. Cytochem

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Section: Discussionsupporting

confidence: 55%

Change in Distribution and Density of CGRP, PGP 9.5, Serotonin and Chromogranin A Immunoreactivity in the Perinatal Rat Respiratory Tract.

Inoue

Fujimiya

Maeda

et al. 1997

Acta Histochem. Cytochem

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“…Various peptides such as bombesin, calcitonin and CGRP, as well as serotonin, have been shown to be transiently increased in the airways during the early life of the rat (Wada et al, 1988), human (Nakatani, 1991) and chicken (Salvi & Renda, 1992). Possible roles of such up-regulated peptides in the maturation of the lung have been discussed through in vivo and in vitro studies (Perks et al, 1992;Speirs et al, 1993;Sunday et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Localization of [D-Ala2]deltorphin I-like immunoreactivity in perinatal rat respiratory system

et al. 1994

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The localization of [D-Ala2]deltorphin I, a delta-opioid receptor ligand, was studied in the lower respiratory tract of developing rats using an immunohistochemical method. [D-Ala2]-like immunoreactive cells were detected first in the principal bronchus as early as embryonic day 16. As embryos grew, positive cells became gradually visible everywhere from principal bronchi to respiratory bronchioles. The density of positive cells reached the highest level on embryonic day 21, but decreased gradually after birth. Positive cells were no longer seen on postnatal day 30 in any region of the airways. No positive cells were ever found in the trachea or alveoli of rats at any age studied. Ultrastructural examination indicated that the immunoreactive cells possessed a similar morphology to serous or Clara cells of the respiratory epithelium. Immunoreaction products tended to locate at the apical cytoplasm of positive cells. The results suggests that [D-Ala2]-like molecule(s) may be expressed transiently in serous cells or Clara cells, or both, of the rat bronchopulmonary tract. Such a molecule may act as a pulmonary growth-promoting or a differentiation-initiating factor in an early period of lung development.

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“…The lack of information on the ontogeny in chicken gut prompted us to undertake an immunohistochemical study to complete our research project on the ontogeny of the neuroendocrine system of the chicken. We previously reported data about the ontogeny of GAL-IR nervous elements in the chicken lung (Salvi and Renda, 1992) and in the chicken esophagus (Salvi et al, 1998).…”

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confidence: 99%

Ontogeny of galanin-immunoreactive elements in the intrinsic nervous system of the chicken gut

1999

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Galanin is a brain-gut peptide that is present in the central and peripheral nervous systems. In the gut, it is contained exclusively in intrinsic and extrinsic nerve supplies, and it is involved overall in the regulation of gut motility. To obtain information about the ontogeny of galanin, we undertook an immunohistochemical study of chicken embryos.The time of first appearance and the distribution patterns of galanin were investigated with fluorescence and streptavidin-biotin-peroxidase (ABC) immunohistochemical protocols by using a galanin polyclonal antiserum. The various regions of the gut and the pancreas were obtained from chicken embryos aged from 3 days of incubation to hatching. All specimens were fixed in buffered picric acid-paraformaldehyde, frozen, and cut with a cryostat.Galanin-immunoreactive neuroblasts were first detected at 4 days in the mesenchyme of the proventriculus/gizzard primordium and within the Remak ganglion. They then extended cranially and caudally, reaching all of the other gut regions at 6.5 days. Galanin-immunoreactive nerve elements mainly occupied the sites of myenteric and submucous plexuses. From day 15, galanin-immunoreactive nerve fibers tended to invade the circular muscular layer and part of the lamina propria of the mucosa. In the pancreas, weak galanin-immunoreactive nerve elements were detected at 5.5 days. They tended to be distributed among the glandular lobules according to the organ differentiation.The widespread distribution during the earlier embryonic stages represents evidence indicating that the neuropeptide galanin may have a role as a differentiating or growth factor. From late embryonic life, its predominant presence in sympathetic nerves and in muscular layers fits with the functions demonstrated previously in adults of other vertebrates for galanin as a modulator of intestinal motility. Anat Rec 254: 28-38, 1999. 1999 Wiley-Liss, Inc.

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An Immunohistochemical Study on Neurons and Paraneurons of the Pre- and Post-Natal Chicken Lung.

Cited by 17 publications

References 32 publications

Change in Distribution and Density of CGRP, PGP 9.5, Serotonin and Chromogranin A Immunoreactivity in the Perinatal Rat Respiratory Tract.

Change in Distribution and Density of CGRP, PGP 9.5, Serotonin and Chromogranin A Immunoreactivity in the Perinatal Rat Respiratory Tract.

Localization of [D-Ala2]deltorphin I-like immunoreactivity in perinatal rat respiratory system

Ontogeny of galanin-immunoreactive elements in the intrinsic nervous system of the chicken gut

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