1971
DOI: 10.1111/j.1600-065x.1971.tb00462.x
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An Immunostimulation Theory of Tumor Development

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Cited by 88 publications
(53 citation statements)
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References 110 publications
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“…It seems feasible that the role of macrophages (and bone-marrow-containing monocytemacrophage precursors) might be in antigen processing or in increased availability for effector function (specific or nonspecific), or both. In effect, a considerable body of evidence shows that the immune defect in neonates can be repaired by adult macrophages or their precursors (Argyris, 1968;Blaese, 1975 The increased frequency of tumours observed in the newborn recipients after the transfer of low numbers of spleen, neutrophils or thymus cells may be the result of a mechanism of tumour immunostimulation as proposed by Prehn (1972), Prehn and Lappe (1971). An apparently similar block or enhancement exerted by different cell numbers has been reported in several systems, both in vitro (Prehn, 1972;Klein, 1972;Fidler, 1973;Fidler, Brodey and Bech-Nielsen, 1974;Kall and Hellstrom, 1975;Nathan and Terry, 1975) and in vivo (Belayev and Gruntenko, 1972;Fidler, 1974;Carnaud et al, 1974;Umiel and Trainin, 1974).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It seems feasible that the role of macrophages (and bone-marrow-containing monocytemacrophage precursors) might be in antigen processing or in increased availability for effector function (specific or nonspecific), or both. In effect, a considerable body of evidence shows that the immune defect in neonates can be repaired by adult macrophages or their precursors (Argyris, 1968;Blaese, 1975 The increased frequency of tumours observed in the newborn recipients after the transfer of low numbers of spleen, neutrophils or thymus cells may be the result of a mechanism of tumour immunostimulation as proposed by Prehn (1972), Prehn and Lappe (1971). An apparently similar block or enhancement exerted by different cell numbers has been reported in several systems, both in vitro (Prehn, 1972;Klein, 1972;Fidler, 1973;Fidler, Brodey and Bech-Nielsen, 1974;Kall and Hellstrom, 1975;Nathan and Terry, 1975) and in vivo (Belayev and Gruntenko, 1972;Fidler, 1974;Carnaud et al, 1974;Umiel and Trainin, 1974).…”
Section: Discussionmentioning
confidence: 99%
“…These contrasting findings can be interpreted by the theory, advanced by Prehn, that the effect of immunity might be biphasic, that is, a mild incipient immune response may be stimulatory to tumour growth but a strong one can be inhibitory (Prehn and Lappe, 1971).…”
mentioning
confidence: 99%
“…The association between inflammation and cancer has been recognized for over a century and has led some to suggest that under some circumstances, a weak immune response promotes, rather than inhibits the development of cancer [32][33][34]. Recent studies demonstrated that αβ T cell deficiency was associated with reduced progression of chemically induced cancers [35,36].…”
Section: Neither Fish Nor Foul: Tumor-promoting Cd8 + T Cells Withoutmentioning
confidence: 99%
“…His description is presumably the first report of the link between inflammation and cancer. In the 1970s, Prehn proposed that immune effector cells contributed to carcinogenesis and named the phenomenon as "immunostimulation theory of tumor development" [4]. In the 1980s, cancer epidemiological studies identified chronic infections and inflammation as the major risk factors of various types of cancer.…”
Section: Inflammation-based Carcinogenesismentioning
confidence: 99%