An impact of Deoxynivalenol produced by Fusarium graminearum on broiler chickens

Yu, Yu-Hsiang; Hsiao, Felix Shih-Hsiang; Proskura, Witold Stanisław; Dybus, Andrzej; Siao, Y.‐H.; Cheng, Yeong-Hsiang

doi:10.1111/jpn.12883

Cited by 19 publications

(24 citation statements)

References 25 publications

(37 reference statements)

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“…Growth performance parameters of broiler chickens were not affected by DON guidance value (5 mg/kg) inclusion in experimental groups in present study. Likewise, lack of effect of DON at 5 mg/kg in feed on body weight gain, feed intake and feed conversion ratio was reported by researchers [ 22 , 23 ]. Even at 10 mg/kg tested in broiler diets, body weight, bodyweight gain, feed intake, and feed conversion ratio were not adversely affected for 35 d [ 7 , 8 ] and for 42 d [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 79%

“…It was reported that DON could reduce villus height, which was explained by villus contraction and resulted in nutrient transport and utilization impairment and, therefore, could impair zootechnical parameters [ 23 , 37 ]. However, in the current study, this decrease did not reach statistical significance, probably due to the difference of number of samples between treatments.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Deoxynivalenol-Contaminated Diets on Productive, Morphological, and Physiological Indicators in Broiler Chickens

Riahi

Marquis

Ramos

et al. 2020

Animals

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The present study with 1-day-old male broilers (Ross 308) was conducted to evaluate the effects of deoxynivalenol (DON) at different levels (5 and 15 mg/kg feed) on growth performance, relative weight of organs, morphology of the small intestine, serum biochemistry, and welfare parameters of broiler chickens. Forty-five broiler chicks were randomly divided into three different experimental groups with five replicates each: (1) control group received a non-contaminated diet, (2) contaminated diet with 5 mg DON/kg of feed, and (3) contaminated diet with 15 mg DON/kg of feed for 42 days. Results showed that feed artificially contaminated with DON at guidance level (5 mg/kg diet) did not affect growth performance parameters. However, 15 mg/kg reduced body weight gain and altered feed efficiency. DON at two assayed levels significantly increased the absolute and relative weight of thymus and the relative weight of gizzard and decreased the absolute and the relative weight of the colon. Compared to controls, both doses affected small intestine morphometry parameters. In terms of biochemical indicators, DON at 5 mg/kg reduced the creatine kinase level and at 15 mg/kg DON reduced the cholesterol level. Furthermore, DON at 15 mg/kg induced more fear in broilers compared to broilers fed the guidance level. It was concluded that even the guidance level of DON did not affect the chickens’ performance. However, its toxic effect occurred in some organs and biochemical parameters.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Effects of Deoxynivalenol-Contaminated Diets on Productive, Morphological, and Physiological Indicators in Broiler Chickens

Riahi

Marquis

Ramos

et al. 2020

Animals

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“…According to the procedures described by Yu et al. (2018) , DON was manufactured by inoculating rice with Fusarium graminearum ACCC 37687 and then was prepared into powder.…”

Section: Methodsmentioning

confidence: 99%

Gut microbiota mediates the protective role of Lactobacillus plantarum in ameliorating deoxynivalenol-induced apoptosis and intestinal inflammation of broiler chickens

et al. 2020

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The protection of Lactobacillus plantarum JM113 against deoxynivalenol ( DON )-induced apoptosis and intestinal inflammation on the jejunum of broiler chickens and the potential roles of gut microbiota were determined. A total of 144 one-day-old male broilers (Arbor Acres) were randomly divided into 3 treatment groups consisting of 6 replicates with 8 birds per replicate, including the CON (basal diet), the DON (basal diet + 10 mg/kg DON), and the DL (basal diet + 10 mg/kg DON + 1 × 10 9 CFU/kg L. plantarum JM113). The DON-diet decreased ( P < 0.05) the mRNA expression of mucosal defense proteins and mechanistic target of rapamycin pathway genes. Meanwhile, DON challenge significantly increased Bcl-2-associated X gene/B-cell lymphoma 2 gene ( Bcl-2 ) in the jejunum ( P < 0.05) and demonstrated proapoptosis status. In contrast, the DL group showed normal immunity-related gene expression of jejunal mucosa and manifested a superior antiapoptosis status. Adding L. plantarum JM113 significantly raised ( P < 0.05) propionic acid, n-butyric acid, and total short-chain fatty acids concentrations in cecal contents of birds fed with DON diet. In addition, DON exposure altered bacterial community structure and disturbed the abundance of several bacterial phyla, families, and genera, leading to dysbiosis. Supplementation with JM113 shifted the gut microbiota composition to that of the CON group. Finally, Spearman correlation analysis suggested that most positive correlations with the mRNA expression of immunity-related and apoptosis-regulatory gene were observed within the phylum Bacteroidetes, and most negative correlations with the indicators were observed within the phylum Firmicutes . The mRNA expression of Bcl-2 , TLR2 , mTOR , Raptor , and RPS6KB1 ( P < 0.05), which are regarded as important cell proliferation and antiapoptosis parameters, were significantly negatively associated with the relative abundances of norank_f__Erysipelotrichaceae, Subdoligranulum, and Anaeroplasma , whereas they had a strong positive correlation with Ruminococcaceae_UCG-004 , Alistipes , and Ruminococcaceae_NK4A214_group . These results implied that L. plantarum JM113 supplementation could ameliorate DON-induced apoptosis and intestinal inflammation via manipulating the bacterial community composition and could be used as a potential candidate to attenuate intestinal impairments.

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“…Trichothecenes, as T-2 toxin (Type A) and deoxynivalenol (DON), are produced by Fusarium graminearum and their intoxication cause decrease absorption of glucose [76], and the reduction of villus height and ratio of villus height:crypt depth in broilers [77]. Also, a pro-inflammtory response in the small intestine was observed with the consumption of DON in swine, murine and human's studies [78][79][80].…”

Section: Mycotoxinsmentioning

confidence: 99%

Dietary Factors as Triggers of Low-Grade Chronic Intestinal Inflammation in Poultry

Pont¹,

Farnell²,

Farnell³

et al. 2020

Microorganisms

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Inflammation is the reaction of the immune system to an injury; it is aimed at the recovery and repair of damaged tissue. The inflammatory response can be beneficial to the animal since it will reestablish tissue homeostasis if well regulated. However, if it is not controlled, inflammation might lead to a chronic response with a subsequent loss of tissue function. The intestine is constantly exposed to a number of environmental triggers that stimulate inflammation and lead to a reduction in performance. The diet and dietary components constitute consistent inflammatory triggers in poultry. Dietary components, such as anti-nutritional compounds, oxidized lipids, mycotoxins, and excess of soluble fiber or protein, are all capable of inducing a low-grade inflammatory response in the intestine of broilers throughout a 5-week grow-out period. We hypothesized that dietary factor-induced chronic intestinal inflammation is a key driver of the lower performance and higher incidence of intestinal problems observed in poultry production. Therefore, this review was aimed at exploring feed-induced chronic inflammation in poultry, the constituents of the diet that might act as inflammatory triggers and the possible effects of chronic intestinal inflammation on the poultry industry.

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An impact of Deoxynivalenol produced by Fusarium graminearum on broiler chickens

Cited by 19 publications

References 25 publications

Effects of Deoxynivalenol-Contaminated Diets on Productive, Morphological, and Physiological Indicators in Broiler Chickens

Effects of Deoxynivalenol-Contaminated Diets on Productive, Morphological, and Physiological Indicators in Broiler Chickens

Gut microbiota mediates the protective role of Lactobacillus plantarum in ameliorating deoxynivalenol-induced apoptosis and intestinal inflammation of broiler chickens

Dietary Factors as Triggers of Low-Grade Chronic Intestinal Inflammation in Poultry

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