An impact of glatiramer acetate (timexon) on the signs of neurodegeneration process in the neuronal layer of the retina in patients with relapsing-remitting multiple sclerosis

Sazonov, D V; Бабенко, Л. А.; Yarmoschuk, A. V.; Didrikh, E. M.

doi:10.17116/jnevro201811812125

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…OCT findings revealed that there was an absence and/or reduction in retinal changes or damage after GA administration [38,40]. These studies found that GA had a beneficial, neuroprotective role in retinal axonal degeneration in MS. GA has been shown to improve MS-associated visual pathology, which is in alignment with the other established use of GA in both MS and ADM [51,53].…”

Section: Role Of Ga In Preventing Cognitive Decline In Multiple Scler...supporting

confidence: 70%

Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation

Kasindi

Fuchs

Koronyo

et al. 2022

Cells

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Novel, neuroprotective uses of Copaxone (generic name: glatiramer acetate—GA) are being examined, primarily in neurological conditions involving cognitive decline. GA is a well-studied synthetic copolymer that is FDA-approved for immune-based treatment of relapsing remitting multiple sclerosis (RRMS). Clinical studies have explored the potential mechanism of action (MOA) and outcomes of GA immunization in patients. Furthermore, results from these and animal studies suggest that GA has a direct immunomodulatory effect on adaptive and innate immune cell phenotypes and responses. These MOAs have been postulated to have a common neuroprotective impact in several neuroinflammatory and neurodegenerative diseases. Notably, several clinical studies report that the use of GA mitigated MS-associated cognitive decline. Its propensity to ameliorate neuro-proinflammatory and degenerative processes ignites increased interest in potential alternate uses such as in age-related macular degeneration (AMD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD). Preclinical studies are exploring less frequent subcutaneous administration of GA, such as once weekly or monthly or a single dosing regimen. Indeed, cognitive functions were found to be either preserved, reversed, or improved after the less frequent treatment regimens with GA in animal models of AD. In this systematic review, we examine the potential novel uses of GA across clinical and pre-clinical studies, with evidence for its beneficial impact on cognition. Future investigation in large-size, double-blind clinical trials is warranted to establish the impact of GA immunomodulation on neuroprotection and cognitive preservation in various neurological conditions.

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Section: Role Of Ga In Preventing Cognitive Decline In Multiple Scler...supporting

confidence: 70%

Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation

Kasindi

Fuchs

Koronyo

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

An impact of glatiramer acetate (timexon) on the signs of neurodegeneration process in the neuronal layer of the retina in patients with relapsing-remitting multiple sclerosis

Cited by 1 publication

References 13 publications

Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation

Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation

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