An Implantable Peripheral Nerve Recording and Stimulation System for Experiments on Freely Moving Animal Subjects

Lee, Byunghun; Koripalli, Mukhesh K.; Jia, Yaoyao; Acosta, Joshua; Sendi, Mohammad S.E.; Choi, YongMan; Ghovanloo, Maysam

doi:10.1038/s41598-018-24465-1

Cited by 90 publications

(45 citation statements)

References 47 publications

(46 reference statements)

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“…The most common approaches involve radio frequency (RF) power transmission or electromagnetic induction 13 . Although these technologies are being developed for clinical use 11,[14][15][16] , RF imposes size and shape constraints for transmitting and receiving components. The volume of the receiver (implanted inside the body) ranges from 30-600 mm 3 , 17 including antenna for RF transmission, electrodes for nerve stimulation, and device packaging for protection of rigid Si-based electronics from body fluids.…”

mentioning

confidence: 99%

A chronic photocapacitor implant for noninvasive neurostimulation with deep red light

Silvera-Ejneby

Jakešová

Ferrero

et al. 2020

Preprint

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AbstractImplantable clinical neuroelectronic devices are limited by a lack of reliable, safe, and minimally invasive methods to wirelessly modulate neural tissue. Here, we address this challenge by using organic electrolytic photocapacitors (OEPCs) to perform chronic peripheral nerve stimulation via transduction of tissue-penetrating deep-red light into electrical signals. The operating principle of the OEPC relies on efficient charge generation by nanoscale organic semiconductors comprising nontoxic commercial pigments. OEPCs integrated on an ultrathin cuff are implanted, and light impulses at wavelengths in the tissue transparency window are used to stimulate from outside of the body. Typical stimulation parameters involve irradiation with pulses of 50-1000 μs length (638 or 660 nm), capable of actuating the implant about 10 mm below the skin. We detail how to benchmark performance parameters of OEPCs first ex vivo, and in vivo using a rat sciatic nerve. Incorporation of a microfabricated zip-tie mechanism enabled stable, long-term nerve implantation of OEPC devices in rats, with sustained ability to non-invasively mediate neurostimulation over 100 days. OEPC devices introduce a high performance, ultralow volume (0.1 mm3), biocompatible approach to wireless neuromodulation, with potential applicability to an array of clinical bioelectronics.

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mentioning

confidence: 99%

A chronic photocapacitor implant for noninvasive neurostimulation with deep red light

Silvera-Ejneby

Jakešová

Ferrero

et al. 2020

Preprint

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“…However, because almost all peripheral nerves are mixed, stimulation-based therapeutic approaches require the separated regeneration of sensory and motor axons. The second reason is to connect the sensory and motor nerves of the amputees to the sensors and actuators of the bionic neuroprostheses that are being available in the market, which demand well-differentiated and ordered sensory and motor axons to be separately guided and connected to the artificial sensors and actuators (Raspopovic et al, 2014;Micera, 2016;Lee et al, 2018;Günter et al, 2019;Deshmukh et al, 2020).…”

Section: The Need Of An Ordered and Differentiated Regeneration Of Sementioning

confidence: 99%

Biomimetic Approaches for Separated Regeneration of Sensory and Motor Fibers in Amputee People: Necessary Conditions for Functional Integration of Sensory–Motor Prostheses With the Peripheral Nerves

Guedan-Duran

Jemni-Damer

Orueta-Zenarruzabeitia

et al. 2020

Front. Bioeng. Biotechnol.

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“…The longer-term procedure especially requires miniaturized and wireless devices to ensure patients' comfort and flexibility [7][8][9]. The wireless neural interface is also suitable for preclinical experiments with nonhuman behaving animals [10][11][12][13]. The wireless nature of the experiment ensures untethered movement during the procedure [14]; hence, more naturalistic brain signal recording is possible.…”

Section: Introductionmentioning

confidence: 99%

“…The wireless neural interface is gaining popularity due to its convenience and flexibility. Most studies are primarily concentrated on wireless communication technology [11,12], wireless power transmission techniques [13,22] and compatible electrode development [23,24]. Only a few of them focus on dedicated signal processing algorithms for neural data [25,26].…”

Section: Introductionmentioning

confidence: 99%

An FPGA-Based Neuron Activity Extraction Unit for a Wireless Neural Interface

et al. 2020

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As computational and functional brain model development are solely dependent upon the data acquired from the neural interface, this device plays a vital role in both prosthetic developments and neurological experiments. A wireless neural interface is preferred over a traditional wired one because it can maximize the comfort of the subject and ensure the freedom of movement while implemented. This paper describes the field programmable gate array (FPGA) prototype design of a low-power multichannel neuron activity extraction unit suitable for a wireless neural interface. To achieve the low-power requirement, we proposed a novel neural signal extraction algorithm which can provide an up to 6000X transmission rate reduction considering the input signal. Consequently, this technique offers at least 2X power reduction compared to the state-of-the-art systems. We implemented this scheme in Xilinx Zynq-7000 FPGA, which can be used as an intermediate transition towards the application specific integrated circuit (ASIC) design for on-chip neural signal processing. The proposed FPGA prototype offers reconfigurable computability, which means the model can be modified and verified according to prerequisites before the final ASIC design. This prototype consists of a signal filtering unit and a signal extraction unit which can be used either as stand-alone units or combined as a complete system. Our proposed scheme also provides a provision to work as a single-channel or a scalable multichannel interface based on user’s demands. We collected practical neural signals from rat brains and validated the efficacy of the implemented system using in-silico signal processing.

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An Implantable Peripheral Nerve Recording and Stimulation System for Experiments on Freely Moving Animal Subjects

Cited by 90 publications

References 47 publications

A chronic photocapacitor implant for noninvasive neurostimulation with deep red light

A chronic photocapacitor implant for noninvasive neurostimulation with deep red light

Biomimetic Approaches for Separated Regeneration of Sensory and Motor Fibers in Amputee People: Necessary Conditions for Functional Integration of Sensory–Motor Prostheses With the Peripheral Nerves

An FPGA-Based Neuron Activity Extraction Unit for a Wireless Neural Interface

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