An important link between the gut microbiota and the circadian rhythm: imply for treatments of circadian rhythm sleep disorder

Tian, Yufei; Yang, Weng Lang; Chen, Gang; Men, Chuanlong; Gu, Yifan; Song, Xiaoran; Zhang, Ruilin; Wang, Laiyou; Zhang, Xin

doi:10.1007/s10068-021-01015-6

Cited by 13 publications

(4 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, the richness, number, and composition of the intestinal microbiota of insomnia individuals were changed, which mainly manifested as a decrease in the abundance and number of intestinal beneficial bacteria as well as an increase in the abundance and number of harmful bacteria. 35 In line with this finding, we also found that compared with the Model group, both cow milk and goat milk could promote the growth of Bifidobacteria . Bifidobacteria , one of the important probiotics in the gut, can use lactose to produce lactic acid, inhibiting the growth of pathogenic bacteria.…”

Section: Discussionsupporting

confidence: 81%

Goat and cow milk differ in altering the microbiota composition and neurotransmitter levels in insomnia mouse models

Mo¹,

Jing²,

Du³

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 81%

Goat and cow milk differ in altering the microbiota composition and neurotransmitter levels in insomnia mouse models

Mo¹,

Jing²,

Du³

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Shift work in confined environments, leading to sleep deprivation, can disrupt the rhythmic oscillations of Bacteroides , a finding that corroborates Li et al’s research [ 31 ]. Additionally, sleep deprivation can weaken our immune function through changes in the gut microbiota [ 32 , 33 , 34 ]. Furthermore, disorders of gene expression involved in liver rhythm regulation, such as those of Bmal1 and Clock , were observed in high-energy diet models and are related to Bacteroides [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

A Cross Talking between the Gut Microbiota and Metabolites of Participants in a Confined Environment

Song,

Wang,

Xia

et al. 2024

Nutrients

View full text Add to dashboard Cite

Certain workplaces, like deep-sea voyages, subject workers to chronic psychological stress and circadian rhythm disorders due to confined environments and frequent shifts. In this study, participants lived in a strictly controlled confined environment, and we analyzed the effects of a confined environment on gut microbiota and metabolites. The results showed that living in confined environments can significantly alter both the gut microbiota and the gut metabolome, particularly affecting lipid metabolism pathways like glycerophospholipid metabolism. There was a significant reduction in the abundance of Faecalibacterium and Bacteroides, while Blautia, Bifidobacterium, and Collinsella showed significant increases. An association analysis revealed a strong correlation between changes in the gut microbiota and the metabolome. Four upregulated lipid metabolites may serve as biomarkers for damage induced by confined environments, and certain gut microbiota alterations, such as those involving Faecalibacterium and Bacteroides, could be potential psychobiotics or therapeutic targets for enhancing mental health in a confined environment.

show abstract

“…Recent studies have shown that the normal operation of the host biological clock depends on the diurnal variation of the gut microbiota. [ 31 ] The rhythm disruption can cause intestinal flora imbalance, bacterial diversity decrease, and Firmicutes / Bacteroidetes (F/B) ratio increase. [ 32 ] In Bmal1 −/− mice, the abundance of Bacteroidota was absolute decreased.…”

Section: Discussionmentioning

confidence: 99%

Dietary Oat β‐Glucan Alleviates High‐Fat Induced Insulin Resistance through Regulating Circadian Clock and Gut Microbiome

Wang,

Ye,

Wang

et al. 2024

Molecular Nutrition Food Res

View full text Add to dashboard Cite

ScopeHigh‐fat diet induced circadian rhythm disorders (CRD) are associated with metabolic diseases. As the main functional bioactive component in oat, β‐glucan (GLU) can improve metabolic disorders, however its regulatory effect on CRD remains unclear. In this research, the effects of GLU on high‐fat diet induced insulin resistance and its mechanisms are investigated, especially focusing on circadian rhythm‐related process.Methods and resultsMale C57BL/6 mice are fed a low fat diet, a high‐fat diet (HFD), and HFD supplemented 3% GLU for 13 weeks. The results show that GLU treatment alleviates HFD‐induced insulin resistance and intestinal barrier dysfunction in obese mice. The rhythmic expressions of circadian clock genes (Bmal1, Clock, and Cry1) in the colon impaired by HFD diet are also restored by GLU. Further analysis shows that GLU treatment restores the oscillatory nature of gut microbiome, which can enhance glucagon‐like peptide (GLP‐1) secretion via short‐chain fatty acids (SCFAs) mediated activation of G protein‐coupled receptors (GPCRs). Meanwhile, GLU consumption significantly relieves colonic inflammation and insulin resistance through modulating HDAC3/NF‐κB signaling pathway.ConclusionGLU can ameliorate insulin resistance due to its regulation of colonic circadian clock and gut microbiome.

show abstract

An important link between the gut microbiota and the circadian rhythm: imply for treatments of circadian rhythm sleep disorder

Cited by 13 publications

References 66 publications

Goat and cow milk differ in altering the microbiota composition and neurotransmitter levels in insomnia mouse models

Goat and cow milk differ in altering the microbiota composition and neurotransmitter levels in insomnia mouse models

A Cross Talking between the Gut Microbiota and Metabolites of Participants in a Confined Environment

Dietary Oat β‐Glucan Alleviates High‐Fat Induced Insulin Resistance through Regulating Circadian Clock and Gut Microbiome

Contact Info

Product

Resources

About