“…Besides ssDNA binding protein, the two main complexes are a multimeric DNA polymerase holoenzyme and helicase/primase complexes. Given the high molecular weight of such proteins, their nuclear transport has been shown to be an active process mediated by a number of different IMPs, which recognize specific NLSs on the cargo proteins [52,53,54,55,56,57,58,59]. In some cases, individual subunits are capable of localizing to the cell nucleus independently of the others, like in the case of HSV and HCMV DNA polymerase holoenzyme subunits [52,53,54,55,56].…”