An imprinted interpenetrating polymer network for microextraction in packed syringe of carbamazepine

Asgari, Sara; Bagheri, Habib; Es-haghi, Ali; AminiTabrizi, Roya

doi:10.1016/j.chroma.2017.02.033

Cited by 32 publications

(25 citation statements)

References 36 publications

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“…The carbamazepine and clobazam obtained with this method have lower MDLs than the GC obtained with SPE or SPME methods. The MDLs of carbamazepine and clobazam are also lower than those reported using LC coupled to SBSE , MEPS or IL‐DLLME and sweeping‐MEKC coupled to LLE . Although LC with DLLME or SPE combined with DLLME , and GC with USAEME provided comparable results for carbamazepine, elaborate sample preparation procedures or larger sample volume were required.…”

Section: Resultsmentioning

confidence: 74%

“…In recent years, the interest in new extraction with lower sample volume requirements, simpler equipment and handling, and lower reagent consumption has led to the development of several microextraction methods . SPME , stir bar sorptive extraction (SBSE) , microextraction in packed syringe (MEPS) , and dispersive liquid–liquid microextraction (DLLME) have been reported for the extraction of carbamazepine and clobazam from biological fluids. Among these methods, DLLME has attracted much attention because of its speed, ease of operation, low cost, short extraction time, and high enrichment factor (EF).…”

Section: Introductionmentioning

confidence: 99%

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Cyclodextrin‐assisted dispersive liquid–liquid microextraction for the preconcentration of carbamazepine and clobazam with subsequent sweeping micellar electrokinetic chromatography

Chen

Chang

2018

J of Separation Science

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A new version of dispersive liquid-liquid microextraction, namely, cyclodextrin-assisted dispersive liquid-liquid microextraction, with subsequent sweeping micellar electrokinetic chromatography has been developed for the preconcentration and sensitive detection of carbamazepine and clobazam. α-Cyclodextrin and chloroform were used as the dispersive agent and extraction solvent, respectively. After the extraction, carbamazepine and clobazam were analyzed using micellar electrokinetic chromatography with ultraviolet detection. The detection sensitivity was further enhanced using the sweeping technique. Under optimal extraction and stacking conditions, the calibration curves of carbamazepine and clobazam were linear over a concentration range of 2.0-200.0 ng/mL. The method detection limits at a signal-to-noise ratio of 3 were 0.6 and 0.5 ng/mL with sensitivity enhancement factors of 3575 and 4675 for carbamazepine and clobazam, respectively. This developed method demonstrated high sensitivity enhancement factors and was successfully applied to the determination of carbamazepine and clobazam in human urine samples. The precision and accuracy for urine samples were less than 4.2 and 6.9%, respectively.

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Section: Resultsmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Cyclodextrin‐assisted dispersive liquid–liquid microextraction for the preconcentration of carbamazepine and clobazam with subsequent sweeping micellar electrokinetic chromatography

Chen

Chang

2018

J of Separation Science

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“…MIPs have been already developed for the selective extraction of CBZ [7][8][9][10][11][12][13][14][15][16][17][18] using systematically CBZ as template molecule except in one recent study from our group [18]. Indeed, as the synthesis process of the MIP requires the introduction of a large amount of template molecule, and regarding the targeted concentrations in samples, this choice was not considered as relevant.…”

Section: Introductionmentioning

confidence: 99%

“…In most cases, methacrylic acid (MAA) was used as monomer in association with ethylene glycol dimethacrylate (EGDMA) [12,13,15,16], trimethylolpropane trimethacrylate (TRIM) [10,11] or with divinylbenzene (DVB) [7-9, 14, 18] as cross-linker and mainly in acetonitrile, toluene, chloroform and dichloromethane or in some mixtures of these solvents as porogen. A recent study also reports the synthesis of an imprinted interpenetrating polymer network based on a mix of styrene and tetramethoxysilane [17]. Some of the CBZ MIPs were applied to the extraction of CBZ from urine [7,8,16,17], serum [12], or plasma [16] and environmental waters [9,13,14,18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Molecularly Imprinted Polymers for the Selective Extraction of Carbamazepine and Analogs from Human Urine Samples

et al. 2019

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Two molecularly imprinted polymers (MIPs) were synthesized according to a previous work from our group dealing with the extraction of carbamazepine from environmental waters. The potential of these MIPs, that differ by the nature of the monomer used for their synthesis, to selectively extract the drugs carbamazepine and oxcarbazepine and the metabolite 10,11-epoxycarbamazepine was first studied in spiked pure water and a high selectivity was obtained with both MIPs for the three target molecules in this pure media. This selectivity was maintained when applying one of these MIPs to urine samples. Indeed, recoveries of extraction were higher than 82 % on the MIP and lower than 20 % on the corresponding non-imprinted polymer used as a control. The repeatability of the extraction procedure applied to urine was also demonstrated with RSD below 20% for the recoveries of extraction of the three targets at a spiking level of 20 ng.L-1. Limits of quantification between 1 and 7 ng.L-1 were determined for urine sample using the MIP as extraction sorbent combined with LC-MS analysis. The potential of the MIP was compared to the one of Oasis HLB sorbent. This study showed that the MIP constitutes a powerful tool to avoid matrix effects encountered for the quantification of the target molecules in urine sample extracted on Oasis HLB.

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“…Sample preparation remains one of the more time-consuming and error-prone aspects of analytical chemistry. To overcome drawbacks of conventional extraction techniques, innovative miniaturized methods have been mainly proposed as microextraction coupled to solid phase, specifically Solid Phase MicroExtraction (SPME) proposed by Supelco (Bellefonte, Pennsylvania, PA, U.S.), CTC (Zwingen, Switzerlandand), and Restek (Bellefonte, Pennsylvania, PA, U.S.) [37][38][39][40][41], SPME Arrows [42], MicroExctraction by Packed Sorbent (MEPS) [43], Stir Bar Sorptive Extraction (Twister, SBSE) [44], Solid Phase Dynamic Extraction (Magic Needle, SPDE) [45], In-Tube Extraction (ITEX) [46], HiSorb Sorptive Extraction [47], and Monolithic Material Sorptive Extraction (MonoTrap) [48].…”

Section: Introductionmentioning

confidence: 99%

High-Throughput Analysis of Selected Urinary Hydroxy Polycyclic Aromatic Hydrocarbons by an Innovative Automated Solid-Phase Microextraction

Dugheri

Bonari

Gentili

et al. 2018

Preprint

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High-throughput screening of samples is the strategy of choice to detect occupational exposure biomarkers, yet it requires user-friendly apparatus that gives relatively prompt results while ensuring high degrees of selectivity, precision, accuracy and automation, particularly in preparation processes. In the last 10 years, miniaturization has attracted much attention in analytical chemistry and has driven solvent and sample savings and easier automation, the latter thanks to the introduction on the market of three axis autosampler. In light of the above, this contribution describes a novel user-friendly solid-phase microextraction (SPME) off- and on-line platform coupled with gas chromatography triple quadrupole-mass spectrometry to determine urinary 1- and 2-hydroxy-napthalene, 9-hydroxy-phenantrene, 1-hydroxy-pyrene, 3- and 9-hydroxy-benzoantracene and 3-hydroxy-benzo[a]pyrene, metabolites of the related polycyclic aromatic hydrocarbons. In this new procedure chromatography’s sensitivity is combined with the user-friendliness of N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide on-fiber SPME derivatization previous direct immersion sampling, to which is added the quantitative accuracy afforded using specific isotope-labelled internal standards. The detection limits for the seven OH-PAHs were ranged from 0.28 to 1.87 ng/L. Intra-(from 2.5 to 3.0%) and inter-session (from 2.4 to 3.9%) repeatability was also evaluated. This method serves to identify suitable risk-control strategies for occupational hygiene conservation programs

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An imprinted interpenetrating polymer network for microextraction in packed syringe of carbamazepine

Cited by 32 publications

References 36 publications

Cyclodextrin‐assisted dispersive liquid–liquid microextraction for the preconcentration of carbamazepine and clobazam with subsequent sweeping micellar electrokinetic chromatography

Cyclodextrin‐assisted dispersive liquid–liquid microextraction for the preconcentration of carbamazepine and clobazam with subsequent sweeping micellar electrokinetic chromatography

Synthesis and Characterization of Molecularly Imprinted Polymers for the Selective Extraction of Carbamazepine and Analogs from Human Urine Samples

High-Throughput Analysis of Selected Urinary Hydroxy Polycyclic Aromatic Hydrocarbons by an Innovative Automated Solid-Phase Microextraction

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