Accurate prediction of the hydraulic effect of hydrate deposition and plug location is critical to the safety and operability of natural gas transport pipelines, especially for gas-dominant subsea pipelines where maintenance and intervention activities are more difficult. To achieve this, the present work improved an existing two-phase pressure drop relation due to friction, by incorporating the hydrates deposition rate into the equation. In addition, a model has been developed to predict the pipeline plugging time. The transient pressure drop predictions in the present study for all six cases at high and low velocities are within 4% mean relative error. Similar predictions by Di Lorenzo et al. are within 40% maximum relative error, while the mean relative error of the transient pressure drop predictions by Zhang et al. was 7.43%. In addition, the plugging flowtime model underpredicts the plugging time by a mean relative error of 9%.