Toxic gases are responsible for the loss of many human lives around the world, which is increasing every year. Toxicity can have various biological aspects on the human body. The exposure to its gases leads to harmful consequences for the organism, which leads to metabolic reactions and even death. For this purpose, the initial step is to detect these gases with miniature flexible structures and solid progressed estimation methods using a simulation software tool. The studied sensor is based on the frequency characterization of an RF Planar Resonant Structure, in which the active element is a patch of radiating graphene printed on a polyimide film (Kapton). The objective of this work is to use our Graphene-Kapton sensor for non-invasive testing applications. In our case, the device is tested to detect and recognize several dangerous and toxic gases such as Fluorine azide (F2N), Hydrogen Iodide (HI), Nitrogen (N2), Methane (CH4), and Carbon monoxide (CO). The simulation results indicate that the Graphene-Kapton flexible sensor exhibits an important sensing performance. The sensor is able to detect all the tested gases with a good sensitivity depending on each gas. As well as, the sensor shows a high sensitivity (0.1± 0.01)* 106 [ppm]-1 (0.1 [ppt]-1) of methane (CH4) gas with detection limit of (9±0.1) *10-6 ppm (9 ppt).