The study's novel contribution is the development and evaluation of a hybrid encryption scheme combining Elliptic Curve Cryptography (ECC) with the Serpent symmetric encryption algorithm, demonstrating enhanced security and performance for safeguarding healthcare data in cluster environments while ensuring scalability, interoperability, and compliance with HIPAA regulations. The primary objectives include assessing the suitability of the ECC-Serpent hybrid encryption for safeguarding healthcare data, ensuring the scalability and interoperability of this encryption solution with existing healthcare systems, and implementing secure communication channels within cluster environments. The combination of Elliptic Curve Cryptography (ECC) and the Serpent algorithm leverages ECC's efficient key management and Serpent's robust symmetric encryption to provide enhanced security and performance, ensuring scalable and resilient data protection in cluster environments. This hybrid approach addresses both key distribution efficiency and high encryption strength, which are critical for securing sensitive healthcare data. This hybrid approach addresses key distribution efficiency and high encryption strength, which are critical for securing sensitive healthcare data. The study employs a hierarchical key management strategy, utilizing ECC for secure key exchange and distribution, paired with regular key rotation and storage practices to maintain compliance with HIPAA regulations and ensure the ongoing protection of sensitive healthcare data. Overall, the research underscores the critical need for healthcare organizations to adhere to HIPAA regulations and implement robust encryption measures to protect patient privacy and secure sensitive medical information. The study concludes that the ECC-Serpent hybrid encryption scheme is a viable and effective solution for enhancing healthcare data security in cluster environments, ensuring both data integrity and regulatory compliance. The implemented Python framework yielded promising results, the key finding is that the ECC-Serpent hybrid encryption scheme is a viable and effective solution for enhancing healthcare data security in cluster environments, achieving an accuracy rate of 97.5% in safeguarding patient data.