With the rapid development of e-commerce, the backlog of distribution orders, insufficient logistics capacity and other issues are becoming more and more serious. It is very significant for e-commerce platforms and logistics enterprises to clarify the demand of logistics. To meet this need, a forecasting indicator system of Guangdong logistics demand was constructed from the perspective of e-commerce. The GM (1, 1) model and Back Propagation (BP) neural network model were used to simulate and forecast the logistics demand of Guangdong province from 2000 to 2019. The results show that the Guangdong logistics demand forecasting indicator system has good applicability. Compared with the GM (1, 1) model, the BP neural network model has smaller prediction error and more stable prediction results. Based on the results of the study, it is the recommendation of the authors that e-commerce platforms and logistics enterprises should pay attention to the prediction of regional logistics demand, choose scientific forecasting methods, and encourage the implementation of new distribution modes.