An Improved Formula for Hydrpphilic Ointment

Study of Anionic and Cationic Surfactants in a Hydrophilic Ointment Base I. The Screening Program

“…The refrigerator samples showed an increase in consistency except in the case of ointments prepared with Duponol LS, Igepon T-73, 3 and 5% concentrations of B.T.C., and 1 and 5%…”

“…The ointments containing I, 3, and 5% concentrations of Stepanol ME (sodium lanryl sulfate) were used as control ointment samples for the ointments containing corresponding concentrations of a surfactant. The amount of water loss increased with an increase in concentration of surfactant in the three control samples.…”

“…Based on the screening ptocedures to this point the following five surfactants in the concentrations shown below w-ere selected as warranting further study: Lathanol LAL, 3 3 1 1 1 1 1 1 1 3 1 2 1 3.0% 3 1 2 1 1 1 1 1 2 1 2 1 63…”

“…Oil-in-water type emulsion bases have several advantages over and are preferred to water-in-cil emulsion ointment bases (1,2). A representative example of an oil-in-water type emulsion base became official in the U. S. P. XI11 under the title of hydrophilic ointment and has been used extensively since that time (3). The recent development of a wide variety of surfactants has stimulated many workers to evaluate them for use in the formulation of a better hydrophilic ointment Nonionic surfactants have been rather extensively evaluated for their usc in hydrophilic ointment.…”

A Study of the Effect of Nonionic EmulsifyingAgents on the Release of Medicationfrom Hydrophilic Ointment Bases

“…YDROPHILIC OINTMENT U. S. P. XIV has been reported (1) t o possess undesirable compatibility and irritation properties due t o the presence of the anionic surfactant, sodium lauryl sulfate in its formulation. Accordingly, the Revision Committee of the U. S. P. recommended the study of this ointment base in a n effort t o overcome this disadvantage by the use of some available nonionic surfactants.Barr, et al (2), and Lesshafft and DeKay (3) have undertaken this project b y screening the available nonionic surfactants for their emulsifying ability with the subsequent evaluation of the formulations for desirable physical a n d compatibility properties.It is considered equally as important to know the effect of the various surfactants, in varying concentrations, on medicament release; accordingly, this project was undertaken.The literature offers a multiplicity of procedures for the determination of the release of medication from ointment bases. The official agar plate method (4), however, does hold a prominent position with regard to frequency of usage for such a purpose.…”