The analysis of protein-protein interaction networks can transfer the
knowledge of well-studied biological functions to functions that are not yet
adequately investigated by constructing networks and extracting similar
network structures in different species. Multiple network alignment can be
used to find similar regions among multiple networks. In this paper, we
introduce Accurate Combined Clustering Multiple Network Alignment (ACCMNA),
which is a new and accurate multiple network alignment algorithm. It uses
both topology and sequence similarity information. First, the importance of
all the nodes is calculated according to the network structures. Second, the
seed-and-extend framework is used to conduct an iterative search. In each
iteration, a clustering method is combined to generate the alignment.
Extensive experimental results show that ACCMNA outperformed the
state-of-the-art algorithms in producing functionally consistent and
topological conservation alignments within an acceptable running time.