Recent use of satellite observations of aerosol optical depth (AOD) to characterize surface concentrations of particulate matter (PM) air pollution has proven extremely valuable in estimating exposures for health effects studies. While the spatial resolutions of satellite data provide far better coverage than existing fixed site surface monitoring stations, they are not able to capture atmospheric processes such as dilution of primary pollutants that vary at small spatial scales. As a result, small-scale variability due to highly localized sources such as traffic may be poorly represented, which in turn may lead to exposure measurement error in epidemiological analyses. Using a fixed spatial grid representing 4.4 km Multiangle Imaging SpectroRadiometer (MISR) aerosol observations, we examined the spatial variability in fine and coarse mode PM (PM 2.5 and PM 2.5-10 respectively) measured at ground monitors from a unique spatially-dense sampling campaign in Southern California. We found that while the variance in measured PM 2.5 differed seasonally (warm 6.82 µg 2 /m 6 and cool 24.5 µg 2 /m 6 ) across the study region, the average subgrid (<4.4 km) variance did not (warm 2.03 µg 2 /m 6 and cool 2.43 µg 2 /m 6 ) and was significantly smaller. On the other hand, ground monitor PM 2.5-10 concentrations showed large variance in warm (18.6 µg 2 /m 6 ) and cool (20.6 µg 2 /m 6 ) seasons, as well as seasonal differences in subgrid variance (warm 8.90 µg 2 /m 6 and cool 3.28 µg 2 /m 6 ). Geostatistical analysis of the semivariance as a function of distance indicated that variability in measured PM 2.5 and PM 2.5-10 concentrations was relatively constant for spatial scales of one to five kilometers, but there was evidence of small-scale (~500 m) variability in PM 2.5-10 concentrations in the cool season. The lack of small-scale spatial variability in the warm season was likely due to large photochemical contributions to regional PM 2.5 , and greater regional contributions to PM 2.5-10 from windblown dust. In contrast, in the cool season there tends to be greater localized concentrations from primary traffic sources due to stronger nocturnal inversions and delayed morning winds reducing dilution that contribute to greater spatial heterogeneity. Overall, these results suggest that regional contributions tend to dominate PM 2.5 , and spatial resolutions of satellite observations including the 4.4 km MISR and 3 km MODIS aerosol products aptly capture relevant spatial variability. Coarse PM 2.5-10 can have seasonally dependent localized contributions, leading to small-scale variability below current satellite aerosol product resolutions.